Results 111 to 120 of about 253,705 (262)

The BTB/POZ‐MATH Protein ZmBPM1 Interacts With Autophagy‐related Protein ZmATG6 and Modulates the NLR Protein Rp1‐D21‐Mediated Defense Response in Maize

Advanced Science, EarlyView.
The maize BTB/POZ‐MATH (BPM) protein ZmBPM1 interacts with autophagy‐related protein ZmATG6 to relocate the NLR protein Rp1‐D21 from the nucleo‐cytoplasmic compartment into autophagosome‐like puncta, leading to autophagy‐mediated turnover and suppressing the hypersensitive response.
Chang‐Xiao Tang, Tong‐Tong Liu, Qi‐Dong Ge, Xiao‐Ying Liu, Wanxiao Wang, Yang Sun, Yanfei Liu, Faqiang Li, Guan‐Feng Wang   +8 more
wiley   +1 more source

Failure of amino acid homeostasis causes cell death following proteasome inhibition

, 2012
The ubiquitin-proteasome system targets many cellular proteins for degradation and thereby controls most cellular processes. Although it is well established that proteasome inhibition is lethal, the underlying mechanism is unknown.
Christian Münch, Ariane Hanssum, Munch, Christian, Hanssum, Ariane, Amila Suraweera, Suraweera, Amila, Anne Bertolotti, Bertolotti, Anne   +7 more
core   +1 more source

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source

SR‐A3 Promotes USP18‐Mediated deISGylation of STING to Protect Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Yufei Han, Guolin Miao, Yinqi Zhao, Zhiyong Du, Kaikai Lu, Changqi Xiao, Aiden Xian, Jiaxin Duanmu, Zihao Zhou, Jinxuan Chen, Lianxin Zhang, Chao Zhai, Yitong Xu, Zhaoling Li, Xianqin Shen, Sijing Shi, Jingxuan Chen, Si Mei, Yuan Fang, Liwen Zheng, Ling Zhang, Yuhui Wang, Wei Huang, Erdan Dong, Xunde Xian   +24 more
wiley   +1 more source

Inhibitory effects of local anesthetics on the proteasome and their biological actions [PDF]

Local anesthetics (LAs) inhibit endoplasmic reticulum-associated protein degradation, however the mechanisms remain elusive. Here, we show that the clinically used LAs pilsicainide and lidocaine bind directly to the 20S proteasome and inhibit its ...
ヒサトメ, イチロウ, 河田, 康志, イトウ, トシユキ, イノウエ, マサシ, 山口, 博司, Bahrudin, Udin, Obara, Yuji, ニノミヤ, ハルアキ, 1457, Yamaguchi, Hiroshi, 李, 佩俐, バフルディン, ウディン, ヤマグチ, ヒロシ, Saeki, Yasushi, 40464292, 加藤, 克, リ, ペイリ, Kita, Akiko, Tsujitani, Shunichi, Inoue, Masashi, 27414, Ninomiya, Haruaki, 27415, 27418, 27419, 27416, 27417, Li, Peili, 3805, 30304207, 765, 100000877, Kato, Masaru, ツジタニ, シュンイチ, 二宮, 治明, Hisatome, Ichiro, 27425, 井上, 雅史, 27426, 27423, 27424, 27429, 100000183, Morimoto, Yukio, 27427, 27428, 40467709, 27421, 27422, Sakane, Isao, 27420, 100000348, 伊藤, 敏幸, 2609, Nishio, Kazuya, 100000307, 1879, Itoh, Toshiyuki, Murakami, Takuto, Unno, Masaki, 60211504, Kawata, Yasushi, Sugiyama, Rina, カトウ, マサル, カワタ, ヤスシ, 80212124, 100000496, 1367, 100000212, Tanaka, Keiji, 27430, 久留, 一郎, 27431, 40177697   +73 more
core   +1 more source

A New Recruitable E3 Ligase UHRF1 Supporting Targeted Protein Degradation: A Minimal Azide as a Recruitment Ligand

Advanced Science, EarlyView.
Targeted protein degradation is often limited by the scarcity of usable E3 ligases. Herein, we report the first small‐molecule GPX4 degraders that incorporate either electrophilic warheads or a minimal azide group as an E3 recruitment ligand. The azide‐based degrader DK‐5070 effectively drives potent GPX4 degradation; mechanistic studies reveal that ...
Zehong Lin, Kang Duan, Rui Wan, Tao Jiang, Jinzhe Wei, Miao Sun, Mariia A. Skryl'nikova, Maxim A. Gureev, Zhi‐Min Zhang, Zhang Zhang, Ke Ding, Nan Ma, Tongzheng Liu, Yi Tan, Zhengqiu Li   +14 more
wiley   +1 more source

All proteasome-sensitive and proteasome-insensitive sites from human kinases.

, 2016
(a) Proteasome-sensitive sites (purple spheres) mapped onto the PKA structure. Sphere size is proportional to the fraction of ubiquitin modifications that occur at that site.
Nevan J. Krogan (90155), Matthew P. Jacobson (174588), Mary K. Lewinski (2814286), Erik Verschueren (753511), Jeffrey R. Johnson (788972), John Guatelli (247378), K. Aurelia Ball (1323588)   +6 more
core   +1 more source

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source

Lactate‐Induced K370 Lactylation of STING Inhibits STING‐TBK1 Signaling and Dampens Anti‐Tumor Immunity

Advanced Science, EarlyView.
Lactate accumulation in glioblastoma drives lactylation of STING at lysine 370, a primate‐conserved residue. K370 lactylation weakens STING‐TBK1 binding, destabilizes STING, and disrupts ER‐to‐Golgi trafficking, blunting type I interferon signaling. LDHA inhibition reverses K370 lactylation and improves the antitumor efficacy of STING agonism combined ...
Yueyao Wu, Jingzhe Wang, Xu Chen, Yuntong Yang, Ping Wei, Han Xie, Honghao Wang, Chunyu Zhang, Siyi Xu, Qi Wang, Chunlong Zhong, Jing Zhang   +11 more
wiley   +1 more source

Regulation of Arabidopsis thaliana Calcineurin B-like Interacting Protein Kinases (CIPKs) by the Ubiquitin-Proteasome System

, 2017
Ubiquitin Proteasome System (UPS) regulates the abundance of proteins by first attaching ubiquitin molecules and then targeting the modified protein for degradation by the 26S proteasome.
Alotaibi, Dalal
core