Results 261 to 270 of about 411,261 (379)

Tomato Chlorotic Virus Minor Coat Protein Interferes With the Host Proteasome Function by Competitive Disruption of SlPAD1-SlPA4 Interaction to Enhance Viral Infection. [PDF]

Mol Plant Pathol
Wang X, Shang K, Liu W, Wang C, Zhang T, Liu Y, Zhou S, Liu H, Zhu X, Zhu C.   +9 more
europepmc   +1 more source

Base-CP proteasome can serve as a platform for stepwise lid formation [PDF]

, 2015
Zanlin Yu, Nurit Livnat‐Levanon, Oded Kleifeld, Wissam Mansour, Mark A. Nakasone, Carlos A. Castañeda, Emma K. Dixon, David Fushman, Noa Reis, Elah Pick, Michael H. Glickman   +10 more
openalex   +1 more source

PACS‐2 Mitigates NPSC Apoptosis and Intervertebral Disc Degeneration by Preserving MAM Integrity via the SP1/LRRK2/Mfn2 Axis

Advanced Science, EarlyView.
This study investigates the role of PACS‐2 in IDD, demonstrating that it suppresses the nuclear translocation of SP1, thereby downregulating its downstream target LRRK2. This reduces LRRK2‐mediated ubiquitination and degradation of Mfn2 through the JNK pathway, preserving MAM integrity and promoting NPSC survival.
Liang Kang, Jiaqi Wang, Chenhao Zhao, Qiuwei Li, Zhigang Zhang, Huaqing Zhang, Chongyu Jia, Luping Zhou, Yanxin Wang, Yu Chen, Kaixuan Li, Xu Yan, Jie Fang, Haibao Wang, Dandan Wang, Pingping Su, Jingyu Zhang, Zhiwei Chen, Renjie Zhang, Cailiang Shen   +19 more
wiley   +1 more source

Oleanolic Acid Amide Derivatives as 20s Proteasome Stimulators. [PDF]

Chembiochem
Osman JM, Dantis DS, King H, Trader DJ.
europepmc   +1 more source

Cancer Biology of GSPT1: Mechanisms and Targeted Therapy Opportunities of Molecular Glue Degraders

Advanced Science, EarlyView.
This review systemically summarizes the structure, expression, regulatory networks, and isoform‐specific signaling of GSPT1 in cancers. According to the integration of GSPT1 targeted therapies, current challenges of GSPT1 targeted therapies are further analyzed, and provide therapeutic opportunities for the application of GSPT1 degraders in precision ...
Qiqi Lin, Wenjing Liu, Wenjia Lu, Monong Zhao, Lin Cao, Zhiyu Li, Jubo Wang, Xi Xu, Hongxi Wu   +8 more
wiley   +1 more source

The novel human astrovirus VA1 requires the proteasome during cell entry. [PDF]

J Gen Virol
Jiménez LE, López S, Arias CF, López T.   +3 more
europepmc   +1 more source

Effects of the proteasome inhibitor bortezomib in combination with chemotherapy for the treatment of mantle cell lymphoma: a meta-analysis

, 2019
Shi - Jun Li, Jian Hao, Yu Mao, Yu-ling Si   +3 more
openalex   +1 more source

Soybean Auxin Transporter PIN3 Regulates Nitrate Acquisition to Improve Nitrogen Use and Seed Traits

Advanced Science, EarlyView.
Xu et al. discovers that switching off auxin transporters in soybean, PIN3a and PIN3b, disrupts auxin flow; this triggers ARF‐STF3/4 signal cascade to activate the nitrate importer NPF2.13 and soil nitrogen acquisition. Multi‐year field trials show edited soybeans maintain yield with higher oil content, offering a potential genetic route to improve ...
Huifang Xu, Shiyu Huang, Jie Wang, Tian Wang, Qingqing Han, Kexin Wu, Zhen Gao, Xiaolei Shi, Tianli Tu, Ming Wang, Laimei Huang, Jiaomei Chen, Yunqi Liu, Yumei Zhang, Guoqiang Lin, Zhichang Chen, Xu Chen   +16 more
wiley   +1 more source

The Ubiquitin-Proteasome System in Hepatitis B Virus Infection and Hepatocarcinogenesis: Viral Manipulation and Therapeutic Targets. [PDF]

J Microbiol Biotechnol
Han J, Kim KH, Seo SU.
europepmc   +1 more source

CypA Mediates Non‐Small Cell Lung Cancer Chemoresistance by Attenuating Ferroptosis via Stabilizing SLC7A11

Advanced Science, EarlyView.
Summary diagram for the role of CypA in chemoresistance in non‐small cell lung cancer (NSCLC). CypA is overexpressed in chemoresistance NSCLC and drives therapeutic evasion by competitively binding to the K37 site of SLC7A11, thereby blocking TRIM3 mediated K11‐linked ubiquitination and proteasomal degradation, ultimately inhibiting lipid peroxidation ...
Zhongcheng Wang, An Li, Ziwei Song, Xiangming Liu, Yong Ge, Zhiqiao Chen, Yuhui Liu, Boyu Zhang, Hao Zhang, Ting Lan   +9 more
wiley   +1 more source