Results 271 to 280 of about 411,261 (379)

Targeting proteostasis for cancer therapy: current advances, challenges, and future perspectives. [PDF]

Mol Cancer
Zhang C, Li J, Tang Q, Li L, Cao D.
europepmc   +1 more source

Parkin Facilitates the Elimination of Expanded Polyglutamine Proteins and Leads to Preservation of Proteasome Function [PDF]

, 2003
Yien Che Tsai, Paul S. Fishman, Nitish V. Thakor, George A. Oyler   +3 more
openalex   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Substrate structure determines p97- and RAD23A/B-mediated proteasomal degradation in human cells. [PDF]

J Biochem
Ding Y, Tomita T, Tsuchiya H, Saeki Y.
europepmc   +1 more source

Estrogen-Dependent Gene Transcription in Human Breast Cancer Cells Relies upon Proteasome-Dependent Monoubiquitination of Histone H2B [PDF]

, 2011
Tanja Prenzel, Yvonne Begus‐Nahrmann, Frank Krämer, Magali Hennion, Chieh Hsu, Theresa Gorsler, Corinna Hintermair, Dirk Eick, Elisabeth Kremmer, Mikael Simons, Tim Beißbarth, Steven A. Johnsen   +11 more
openalex   +1 more source

Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome

Science, 2016
Yuan Shi, X. Chen, S. Elsasser, B. Stocks, G. Tian, Byung-Hoon Lee, Yanhong Shi, Naixia Zhang, S. A. D. de Poot, Fabian Tuebing, Shuangwu Sun, J. Vannoy, S. Tarasov, J. Engen, D. Finley, K. Walters   +15 more
semanticscholar   +1 more source

The Crosstalk Between CRL5 and APC/C E3 Ligases Regulates Metastasis and Chemosensitivity of Cancer Cells

Advanced Science, EarlyView.
This study uncovers a previously unknown crosstalk between two major ubiquitin ligases, CRL5 and APC/C. The authors identify APC11 as a binding partner of CUL5, showing that their interaction regulates neddylation, substrate stability, and mitotic progression.
Danrui Cui, Ruirui Qu, Tianqi Li, Linchen Wang, Xiaoyu Chen, Shengpeng Shao, Xue Liang, Jun Xu, Yi Sun, Xiufang Xiong, Yongchao Zhao   +10 more
wiley   +1 more source

Peripheral Neuropathy Associated With Proteasome Inhibitors and Immunomodulatory Drugs: A Pharmacovigilance Disproportionality Analysis Using VigiBase. [PDF]

Pharmacol Res Perspect
Braga LP, de Pádua CAM, da Costa IHF, de Miranda Drummond PL, de Souza PHC, Fonseca LB, Rodrigues MA, Malta JS, Reis AMM.   +8 more
europepmc   +1 more source

Proteasome Activity in the Plasma as a Novel Biomarker in Mild Cognitive Impairment with Chronic Tinnitus

, 2020
Yejin Yun, Sang‐Yeon Lee, Won Hoon Choi, Jong‐Chan Park, Dong Han Lee, Yun Kyung Kim, Jung Hoon Lee, Jun‐Young Lee, Min Jae Lee, Young Ho Kim   +9 more
openalex   +2 more sources

TRIM38 Suppresses Breast Cancer Progression via Modulating SQSTM1 Ubiquitination and Autophagic Flux

Advanced Science, EarlyView.
TRIM38, an E3 ubiquitin ligase, suppresses breast cancer progression by inhibiting proliferation, migration, and invasion. Downregulated in breast tumor, its loss correlates with poor prognosis. Mechanistically, TRIM38 mediates K63‐linked ubiquitination of SQSTM1/p62 at K420, disrupting SQSTM1‐LC3 interaction and blocking autophagic flux.
Shan Jiang, Lijuan Wang, Dianwen Han, Peng Su, Bing Chen, Wenjing Zhao, Tong Chen, Ning Zhang, Xiaolong Wang, Yiran Liang, Yaming Li, Chen Li, Xi Chen, Dan Luo, Qifeng Yang   +14 more
wiley   +1 more source