Results 281 to 290 of about 393,592 (390)

Trioxane-based MS-cleavable cross-linking mass spectrometry for profiling multimeric interactions of cellular networks. [PDF]

Nat Commun
Yu C, Novitsky E, Balasubramani SG, Wang X, Shen X, Yang Q, Rychnovsky S, Echeverria I, Huang L.   +8 more
europepmc   +1 more source

Structure of the human 26S proteasome at a resolution of 3.9 Å

Proceedings of the National Academy of Sciences of the United States of America, 2016
A. Schweitzer, Antje Aufderheide, T. Rudack, F. Beck, G. Pfeifer, J. Plitzko, E. Sakata, K. Schulten, F. Förster, W. Baumeister   +9 more
semanticscholar   +1 more source

Autosomal Recessive Cerebellar Ataxias: Translating Genes to Therapies

Annals of Neurology, EarlyView.
Autosomal recessive cerebellar ataxias are disabling neurodegenerative genetic conditions affecting balance and coordination. Advancements in genomic testing have improved diagnosis, leading to a new focus on the development of targeted precision therapeutics addressing cellular, biochemical, and genetic disease mechanisms with a resulting emphasis on ...
Brent L. Fogel, Thomas Klopstock, David R. Lynch, Francesca Maltecca, Mayank Verma, Berge A. Minassian, Frances M. Platt, Débora Farina Gonçalves, Hélène Puccio, Andreas Roos, Matthis Synofzik   +10 more
wiley   +1 more source

CANDLE syndrome: A rare case report documented for the first time in the Middle East. [PDF]

Medicine (Baltimore)
Alhiraki H, Hamdi M, Alhiraki H, Alhiraki I.   +3 more
europepmc   +1 more source

The FindMNDBiomarker Program: Protein Changes in Motor Neuron Disease/Amyotrophic Lateral Sclerosis Postmortem Tissue and Biofluids

Annals of Neurology, EarlyView.
Objective Biomarkers of disease pathogenesis are critically needed for amyotrophic lateral sclerosis (ALS) to facilitate diagnosis and patient stratification into appropriate therapeutic trials. Proteomic studies offer significant potential to advance this, but reproducibility across laboratories is a key component toward identifying protein changes ...
Gabrielle L. Adler, Matthew C. Kiernan, Rachel H. Tan   +2 more
wiley   +1 more source

The Regulatory Particle of the Saccharomyces cerevisiae Proteasome

, 1998
Michael H. Glickman, David M. Rubin, Victor A. Fried, Daniel Finley   +3 more
openalex   +1 more source

p62- and ubiquitin-dependent stress-induced autophagy of the mammalian 26S proteasome

Proceedings of the National Academy of Sciences of the United States of America, 2016
Victoria Cohen‐Kaplan, Ido Livneh, N. Avni, Bertrand Fabre, T. Ziv, Y. Kwon, A. Ciechanover   +6 more
semanticscholar   +1 more source

Progress in Biomimetic Microdevices for Anticancer Drug Screening and their Potential for Enhancing In Vivo Efficacy

Advanced NanoBiomed Research, EarlyView.
Biomimetic microdevices are redefining anticancer drug screening by mimicking complex tumor microenvironments. This review highlights advances in microfluidic systems, cell microarrays, and in vivo‐like models, offering new insights into drug efficacy prediction and personalized medicine. The development of effective anticancer drugs remains a critical
Ching‐Te Kuo, Yen‐Tzu Liao, Hsinyu Lee   +2 more
wiley   +1 more source

Misregulation of the Ubiquitin-Proteasome System and Autophagy in Muscular Dystrophies Associated with the Dystrophin-Glycoprotein Complex. [PDF]

Cells
Bozzi M, Sciandra F, Bigotti MG, Brancaccio A.   +3 more
europepmc   +1 more source

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

Nature Network Boston, 2015
N. Myeku, Catherine L. Clelland, S. Emrani, N. Kukushkin, W. H. Yu, A. Goldberg, K. Duff   +6 more
semanticscholar   +1 more source