Results 311 to 320 of about 393,592 (390)

NFE2L1 as a central regulator of proteostasis in neurodegenerative diseases: interplay with autophagy, ferroptosis, and the proteasome. [PDF]

Front Mol Neurosci
Khodadadi H, Łuczyńska K, Winiarczyk D, Leszczyński P, Taniguchi H.   +4 more
europepmc   +1 more source

Pathological Disulfide Bond Crosslinking: Molecular Insights into Amyloidogenesis and Diseases Progression

ChemBioChem, EarlyView.
This review explores pathological disulfide‐crosslinking as a key driver of amyloidogenic protein misfolding and aggregation. Oxidative and ER stress pathways contributing to disease progression are discussed and emerging therapeutic strategies targeting disulfide‐linked aggregates in neurodegenerative and systemic amyloid diseases are examined ...
Dong Min Kang, Nataliia Lukianenko, Ja‐Hyun Baik, Yun Kyung Kim, Sungsu Lim   +4 more
wiley   +1 more source

Structural Insights into Salinosporamide a Mediated Inhibition of the Human 20S Proteasome. [PDF]

Molecules
Sülzen H, Fajtova P, O'Donoghue AJ, Silhan J, Boura E.   +4 more
europepmc   +1 more source

Internal Ubiquitin Electrophiles for Covalent Trapping and Inhibition of Deubiquitinases

ChemBioChem, Accepted Article.
The ubiquitin (Ub) system governs vital cellular processes in eukaryotic biology through an intricate network of Ub‐protein interactions. While semisynthetic C‐terminal Ub electrophiles (UbEs) are widely used to study Ub transfer and deubiquitinase (Dub) activity, they are limited to probing the active site while leaving other functionally important ...
Chittaranjan Das, Nipuni M. Pannala, Rishi S. Patel, Abhijith Saseendran Anit, Debapriya Bhattacharya, Kristos Negron Teron, Bryon Drown, Rudi Fasan   +7 more
wiley   +1 more source

ELOVL2 mediated stabilization of AR contributes to enzalutamide resistance in prostate cancer. [PDF]

Front Cell Dev Biol
Cen J, Guo J, Zeng X, Song X, Ge S, Chen M, Li Q, Yu Y, Lv D, Zhao S.   +9 more
europepmc   +1 more source

Gold‐Dithiocarbamato Glycoconjugates as Potential Anticancer Agents: Design, Physico‐Chemical Characterization and In Vitro Biological Activity

ChemBioChem, Accepted Article.
In order to develop new metal‐based glycoconjugates as potential anticancer agents, three gold(III)‐dithiocarbamato glycoconjugates of the type [AuIIIBr2(SSC‐Inp‐GlcN)] (Au3‐5), their gold(I)‐phosphine counterparts [AuI(SSC‐Inp‐GlcN)(PPh3)] (AuP3‐5) and gold(I)‐carbene analogues [AuI(SSC‐Inp‐GlcN)(Et2BzImy)] (AuC3‐5) (Inp: isonipecotic moiety; GlcN ...
Andrea Pettenuzzo, Jessica Wölker, Luciano Marchiò, Ingo Ott, Luca Ronconi   +4 more
wiley   +1 more source

Activation of the 20S proteasome core particle prevents cell death induced by oxygen- and glucose deprivation in cultured cortical neurons. [PDF]

Apoptosis
Salazar IL, Curcio M, Mele M, Vetrone R, Frisari S, Costa RO, Caldeira MV, Trader DJ, Duarte CB.   +8 more
europepmc   +1 more source

CALR Type 1‐Like Mutations Increase Endoplasmic Reticulum Free Ca2+ and Induce ERK1/2 Activation Independent of Thrombopoietin Receptor Activation

Cell Biology International, EarlyView.
ABSTRACT Calreticulin is a multifunctional protein found in the endoplasmic reticulum lumen that is important for calcium homeostasis and glycoprotein folding. Mutations in exon 9 of the CALR gene are the second most common genetic cause of myeloproliferative neoplasms.
Mifra Faiz, Caitlin Dunstan‐Harrison, Elizabeth C. Ledgerwood   +2 more
wiley   +1 more source

Ubiquitin-dependent proteolysis of KNL2 driven by APC/CCDC20 is critical for centromere integrity and mitotic fidelity. [PDF]

Plant Cell
Kalidass M, Jarubula VG, Ratnikava M, Chandra JR, Le Goff S, Probst AV, Esposito S, Grasser KD, Bruckmann A, Gagneux JF, Prosée RF, Rutten T, Schubert V, Demidov D, Lechner E, Steiner FA, Genschik P, Lermontova I.   +17 more
europepmc   +1 more source