Results 361 to 370 of about 393,592 (390)
Some of the next articles are maybe not open access.
2012
Cancer is one of the most frightful diseases mostly resulting in mortality; it has recently become more possible to overcome with the help of new therapies. In this direction, carcinogenesis is defined as a complicated process that can include several different factors that contribute to its progress. Proteasome is implicated in cancer studies as it is
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Cancer is one of the most frightful diseases mostly resulting in mortality; it has recently become more possible to overcome with the help of new therapies. In this direction, carcinogenesis is defined as a complicated process that can include several different factors that contribute to its progress. Proteasome is implicated in cancer studies as it is
openaire +2 more sources
2002
The field of intracellular proteolysis has received increasing attention over the last decade. This is due in large part to the fact that, beyond its classical functions that have been acknowledged for a long time, such as destruction of abnormal proteins or cleavage of precursor polypeptides, it was realized during the 1990s that intracellular ...
openaire +3 more sources
The field of intracellular proteolysis has received increasing attention over the last decade. This is due in large part to the fact that, beyond its classical functions that have been acknowledged for a long time, such as destruction of abnormal proteins or cleavage of precursor polypeptides, it was realized during the 1990s that intracellular ...
openaire +3 more sources
Macrocyclic Proteasome Inhibitors
Current Medicinal Chemistry, 2011Proteasome inhibitors have proven to be effective anticancer agents. Despite the success of the first on the market proteasome inhibitor bortezomib in chemotherapy, alternative clinically useful proteasome inhibitors are still urgently needed as bortezomib therapy causes severe side effects and is limited by arising drug resistance.
Krahn, D., Ottmann, C., Kaiser, Markus
openaire +4 more sources
Trends in Cell Biology, 2000
It is well established that ubiquitinated proteins are degraded by the 26S proteasome; however, it is unclear how they are recognized. The S5a subunit of the 26S proteasome is able to bind to polyubiquitin chains, but its role as a substrate recognition site is limited as its deletion in yeast is not lethal and results in minor growth defects.
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It is well established that ubiquitinated proteins are degraded by the 26S proteasome; however, it is unclear how they are recognized. The S5a subunit of the 26S proteasome is able to bind to polyubiquitin chains, but its role as a substrate recognition site is limited as its deletion in yeast is not lethal and results in minor growth defects.
openaire +3 more sources
Structure of 20S proteasome from yeast at 2.4Å resolution
Nature, 1997M. Groll +6 more
semanticscholar +1 more source
The Ubiquitin Code in the Ubiquitin-Proteasome System and Autophagy.
TIBS -Trends in Biochemical Sciences. Regular ed, 2017Y. Kwon, A. Ciechanover
semanticscholar +1 more source
1998
The 26 S proteasome is a large multisubunit complex that degrades intracellular proteins in a nucleotide-dependent reaction. The enzyme is composed of about 30 different proteins. Fourteen subunits are provided by the proteasome and an additional 16 or more subunits are present in a particle that I will call the regulatory complex.
openaire +3 more sources
The 26 S proteasome is a large multisubunit complex that degrades intracellular proteins in a nucleotide-dependent reaction. The enzyme is composed of about 30 different proteins. Fourteen subunits are provided by the proteasome and an additional 16 or more subunits are present in a particle that I will call the regulatory complex.
openaire +3 more sources
Understanding biology to tackle the disease: Multiple myeloma from bench to bedside, and back
Ca-A Cancer Journal for Clinicians, 2014Giada Bianchi, Federico Gago
exaly
Drug discovery in the ubiquitin–proteasome system
Nature Reviews Drug Discovery, 2006Grzegorz Nalepa, J Wade Harper
exaly
Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets
Nature Reviews Drug Discovery, 2011Lawrence R Dick, Marcello Maggiolini
exaly