Results 81 to 90 of about 253,705 (262)
The Role of the Ubiquitin System in Eye Diseases
LifeThe ubiquitin–proteasome system (UPS) is a fundamental process that regulates various biological functions, including immune response, cell cycle, oxidative stress, migration, and cellular proliferation.
Sandra Carolina Durán-Cristiano +3 more
doaj +1 more source
Advanced Science, EarlyView.Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li +8 more
wiley +1 more source
Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity
Advanced Science, EarlyView.This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj +25 more
wiley +1 more source
Recent advances in the treatment of Malaria
Biomedical Research Journal, 2016 Malaria is an infectious disease caused by protozoan parasites belonging to the Plasmodium species. The disease has been a major cause of mortality and morbidity, especially in populations of African and SouthEast Asian countries.
Sohal Satish +4 more
doaj +1 more source
, 2008 A 3D animation showing how proteins in the cell are tagged for disposal and degraded by the proteasome.
Howard Hughes Medical Institute (HHMI)
core
The effects of Parkinson's disease mimetics on the proteasomal and neurofilament systems in SH-SY5Y cells [PDF]
, 2006 Mitochondrial impairment, glutathione depletion and oxidative stress have been implicated in the pathogenesis of Parkinson's disease, linked recently to proteasomal dysfunction.
Caneda-Ferrón, B +1 more
core
Advanced Science, EarlyView.LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao +13 more
wiley +1 more source
Journal of Lipid Research, 2004 Apolipoprotein B (apoB)-48 contains a region termed the β1 domain that is predicted to be composed of extensive amphipathic β-strands. Analysis of truncated apoB variants revealed that sequences between the carboxyl termini of apoB-37 and apoB-42 ...
Louis R. Lapierre +4 more
doaj +1 more source
, 2014 A 3D animation showing how proteins in the cell are tagged for disposal and degraded by the proteasome.
Howard Hughes Medical Institute (HHMI)
core
, 2009 Peroxisome proliferator-activated receptor γ (PPARγ), a member of nuclear hormone receptors, forms a heterodimeric DNA binding complex with retinoid X receptor (RXR) and serves as a transcriptional regulator of gene expression.
TSAO, WEI-CHIA;CHI, KWAN-HWA;CHANG, YING-HSIN;LIN, WAN-WAN +1 more
core +1 more source