Protein entanglement misfolding influences whether proteins undergo proteasomal degradation or persist in near-native misfolded states. [PDF]
Jiang Y +3 more
europepmc +1 more source
Ubiquitin receptor-mediated, ubiquitin-independent targeted protein degradation via 26<i>S</i> proteasomes. [PDF]
Park SH +11 more
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The ubiquitin-proteasome system and autophagy as guardians of the cellular proteome. [PDF]
Dikic I.
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Blm10/PA200-Activated 20S Proteasomes Promote α-Synuclein Degradation and Bypass Proteasome Inhibition in Parkinson's Disease Models. [PDF]
Ali TT +7 more
europepmc +1 more source
Stimulating proteasomal degradation in human proteinopathies. [PDF]
Gierisch ME, Barchi E, Dantuma NP.
europepmc +1 more source
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[24] Multicatalytic endopeptidase complex: Proteasome
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Proteasomes generate peptides from intracellular endogenous and viral proteins for presentation by MHC class I molecules. During viral infection, interferon-gamma (IFN-gamma) acts as a cytokine altering the catalytic specificity of proteasomes by inducing the synthesis of the three proteasome subunits, low molecular weight protein (LMP) 2, LMP7 and ...
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Multicatalytic endopeptidase complex: proteasome.
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