Results 191 to 200 of about 3,106,146 (396)

Microcystin‐LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity

Advanced Science, EarlyView.
MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang, Qi Gao, Yi Peng, Huan Zhang, Qi Shen, Meihong Guo, Yuqing Gong, Lei Chu, Weidong Wu, Yanting Wen, Wangsen Cao, Yong Wang, Lihui Wang   +12 more
wiley   +1 more source

A769662, a novel activator of AMP‐activated protein kinase, inhibits non‐proteolytic components of the 26S proteasome by an AMPK‐independent mechanism

, 2008
Daniel Moreno-Andrés, Erwin Knecht, Benoı̂t Viollet, Pascual Sanz   +3 more
openalex   +2 more sources

QS11. Proteasome Inhibitors Effectively Inhibit Venous and Lymphatic Malformations

, 2022
Noa Shapiro-Franklin, Emma Iaconetti, Ajit Muley, Hai Li, Charles Karan, Carrie J. Shawber, June K. Wu   +6 more
openalex   +1 more source

A20 Facilitates Oxaliplatin Sensitivity in Colorectal Cancer Through Monoubiquitylation of IKK‐β

Advanced Science, EarlyView.
This study demonstrates that the expression of A20, a ubiquitin‐editing enzyme, is positively correlated with oxaliplatin sensitivity in colorectal cancer (CRC). Mechanistically, A20 enhances oxaliplatin sensitivity by inhibiting NF‐κB nuclear translocation through monoubiquitination of IKK‐β.
Fan Luo, Ting Yang, Jiaxin Cao, Qun Chen, Zhenhai Lu, Feiteng Lu, Chaozhuo Lin, Zengfei Xia, Yuanzhong Yang, Peng Li, Wenjuan Ma, Min Luo, Rongxin Zhang   +12 more
wiley   +1 more source

Improving the efficacy of proteasome inhibitors in the treatment of renal cell carcinoma by combination with the human immunodeficiency virus ( HIV )‐protease inhibitors lopinavir or nelfinavir [PDF]

, 2017
Dominik Abt, Andrej Bešše, Lenka Sedlaříková, Marianne Kraus, Juergen Bader, Tobias Silzle, Martina Vodinská, Ondřej Slabý, Hans‐Peter Schmid, Daniel Engeler, Christoph Driessen, Lenka Bešše   +11 more
openalex   +1 more source

Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma

Proceedings of the National Academy of Sciences of the United States of America, 2016
T. Hideshima, J. Qi, Ronald M. Paranal, Weiping Tang, E. Greenberg, N. West, M. Colling, G. Estiu, Ralph Mazitschek, J. Perry, H. Ohguchi, F. Cottini, N. Mimura, G. Görgün, Y. Tai, P. Richardson, Ruben D Carrasco, O. Wiest, S. Schreiber, K. Anderson, J. Bradner   +20 more
semanticscholar   +1 more source

PFOS Disrupts Oocyte Maturation and Early Embryonic Development via Ovarian FOXK1 O‐GlcNAcylation in Mice

Advanced Science, EarlyView.
Perfluorooctane sulfonate (PFOS) exposure disrupts oocyte maturation and early embryonic development. This study elucidates the mechanism by which enhanced O‐GlcNAcylation of FOXK1 underlies the PFOS‐induced reduction of progesterone levels in granulosa cells and the disturbance of follicular microenvironment.
Shuwen Han, Qin Yuan, Zhu Wu, Yaohui Fang, Hong Qian, Jiale Zhu, Yuchen Zhang, Ke Deng, Liangliang Su, Haibo Xu, Haotian Shu, Yiming Gong, Qiaoqiao Xu, Guizhen Du, Di Wu, Yun Fan, Chuncheng Lu   +16 more
wiley   +1 more source

Conserved signal peptide of Notch3 inhibits interaction with proteasome

, 2007
Yanmei Zhang, Lijun Jia, Soo Jung Lee, Michael M. Wang   +3 more
openalex   +1 more source

Proteasome inhibitor associated thrombotic microangiopathy

American journal of hematology/oncology, 2016
J. Yui, J. V. Van Keer, B. Weiss, A. Waxman, M. Palmer, V. D’Agati, E. Kastritis, M. Dimopoulos, R. Vij, D. Bansal, D. Dingli, S. Nasr, N. Leung   +12 more
semanticscholar   +1 more source

Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation

Advanced Science, EarlyView.
Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong, Aima Huang, Ziqing Zhao, Bikai Lai, Xin Pan, Huiyu Yang, Xiaohan Xu, Tianwei Wang, Fangchen Zhao, Zhimin Zhang, Yongbo Xue, Guanjun Deng, Wenbin Deng, Jianwei Chen   +13 more
wiley   +1 more source