Results 251 to 260 of about 3,106,146 (396)

Synthesis and Evaluation of Derivatives of the Proteasome Deubiquitinase Inhibitor b‐AP15

Chemical Biology and Drug Design, 2015
Xin Wang, Padraig D'arcy, T. Caulfield, A. Paulus, K. Chitta, Chitralekha Mohanty, J. Gullbo, A. Chanan-Khan, S. Linder   +8 more
semanticscholar   +1 more source

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, EarlyView.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

Inhibitors of the eukaryotic 20S proteasome core particle: a structural approach [PDF]

, 2005
M. Groll
openalex   +1 more source

The Prognostic Value of Immunophenotypic Characteristics of Plasma Cells in Newly Diagnosed Multiple Myeloma Patients Treated with First-Generation Proteasome Inhibitor Bortezomib

, 2022
Galina Salogub, Ekaterina Rusanova, М. В. Горчакова, Elena Belyakova   +3 more
openalex   +1 more source

Correction: Lysin (K)-specific demethylase 1 inhibition enhances proteasome inhibitor response and overcomes drug resistance in multiple myeloma. [PDF]

Exp Hematol Oncol
Bandini C, Mereu E, Paradzik T, Labrador M, Maccagno M, Cumerlato M, Oreglia F, Prever L, Manicardi V, Taiana E, Ronchetti D, D'Agostino M, Gay F, Larocca A, Besse L, Merlo GR, Hirsch E, Ciarrocchi A, Inghirami G, Neri A, Piva R.   +20 more
europepmc   +1 more source

Therapeutic implications of mitochondrial stress-induced proteasome inhibitor resistance in multiple myeloma. [PDF]

Sci Adv, 2022
Sharma A, Nair R, Achreja A, Mittal A, Gupta P, Balakrishnan K, Edgar CL, Animasahun O, Dwivedi B, Barwick BG, Gupta VA, Matulis SM, Bhasin M, Lonial S, Nooka AK, Wiita AP, Boise LH, Nagrath D, Shanmugam M.   +18 more
europepmc   +1 more source

MG132, a proteasome inhibitor, induces apoptosis in tumor cells

Asia-Pacific Journal of Clinical Oncology, 2013
Na Guo, Zhilan Peng
semanticscholar   +1 more source

A Reactive Antagonist Strategy: Cysteine‐Directed Covalent Molecular Glue in Plant Hormone Receptor Regulation

Advanced Science, EarlyView.
The plant hormone jasmonate is perceived by COI1‐JAZ co‐receptors comprising a single F‐box protein COI1 and multiple JAZ repressors with overlapping functions, complicating genetic analysis. We present a reactive antagonist (RA) strategy that selectively promotes COI1 binding to a cysteine‐engineered JAZ variant while blocking wild‐type JAZs, enabling
Minoru Ueda, Kotaro Matsumoto, Takao Nomura, Yousuke Takaoka, Taichi Okumura, Wataru Kozaki, Hikaru Hoshikawa, Yuho Nishizato, Andrea Chini, Roberto Solano, Katsumi Maenaka   +10 more
wiley   +1 more source

Proteasome inhibitors prevent bi-directional HER2/estrogen-receptor cross-talk leading to cell death in endocrine and lapatinib-resistant HER2+/ER+ breast cancer cells

, 2017
Sonja Thaler, Martina Schmidt, Gitta Thiede, Aimee Schad, Jonathan P. Sleeman, Jonathan P. Sleeman   +5 more
openalex   +2 more sources

Anti-tumor effect of proteasome inhibitor on canine urothelial carcinoma. [PDF]

J Vet Med Sci
Kodera Y, Iguchi T, Kato D, Ikeda N, Shinada M, Aoki S, Soga K, Li T, Ohata R, Koseki S, Shibahara H, Takahashi Y, Hashimoto Y, Nishimura R, Nakagawa T.   +14 more
europepmc   +1 more source