Results 281 to 290 of about 3,106,146 (396)

The Proteasome Inhibitor Marizomib Evokes Endoplasmic Reticulum Stress and Promotes Apoptosis in Human Glioblastoma Cells. [PDF]

Pharmaceuticals (Basel)
Kusaczuk M, Tyszka N, Krętowski R, Cechowska-Pasko M.   +3 more
europepmc   +1 more source

Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity.

Proceedings of the National Academy of Sciences of the United States of America, 1999
Lihao Meng, R. Mohan, B. Kwok, Mikael Elofsson, N. Sin, C. Crews   +5 more
semanticscholar   +1 more source

Xanthatin Targets CISD1 to Drive Ferroptosis and Mitophagy as a Dual Anticancer Strategy in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer has a poor prognosis. Xanthatin directly targets and degrades CISD1, triggering ferroptosis through iron dysregulation. The concurrently activated mitophagy synergistically amplifies ferroptotic cell death. Xanthatin also demonstrates potent in vivo anti‐tumor efficacy with minimal toxicity, highlighting its therapeutic ...
Qinwen Liu, Haojie Chen, Xiang Li, Jingxin Liu, Yiwen Li, Zhenyi Shi, Shenshen Guo, Qingfeng Du, Aiping Lu, Daogang Guan   +9 more
wiley   +1 more source

Identification of Malaria-Selective Proteasome β5 Inhibitors Through Pharmacophore Modeling, Molecular Docking, and Molecular Dynamics Simulation [PDF]

Muhammad Yasir, Jinyoung Park, Eun‐Taek Han, Jin‐Hee Han, Won Sun Park, Wanjoo Chun   +5 more
openalex   +1 more source

Phase I study of TQB3602, an oral proteasome inhibitor, in relapsed and refractory multiple myeloma. [PDF]

Cancer Med
Tang W, Li Y, Zhang L, Zhong X, Liang Q, Zheng Y, Liu Y, Wang Y, Wang X, Zeng Y, Fang B, Zheng L, Niu T.   +12 more
europepmc   +1 more source

Induction of Tumor Cell Apoptosis by a Proteasome Deubiquitinase Inhibitor Is Associated with Oxidative Stress

Antioxidants and Redox Signaling, 2014
Slavica Brnjic, M. Mazurkiewicz, M. Fryknäs, Chao Sun, Xiaonan Zhang, R. Larsson, Padraig D'arcy, S. Linder   +7 more
semanticscholar   +1 more source

Gut Microbe‐Driven Resistance Mechanisms in Propylea Japonica: Insights from Horizontal Gene Transfer and Oxidative Phosphorylation

Advanced Science, EarlyView.
Acinetobacter regulates dinotefuran tolerance in Propylea japonica by mediating the expression of the horizontally transferred gene PjDUF1. Abstract Insect–microbial symbiont relationships are widespread in nature and often involve lateral gene transfer.
Ningbo HuangFu, Xiangzhen Zhu, Zhijuan Tang, Li Wang, Kaixin Zhang, Dongyang Li, Jichao Ji, Jinjie Cui, Zhaojiang Guo, Junyu Luo, Xueke Gao   +10 more
wiley   +1 more source

Differential Interactions of the Proteasome Inhibitor PI31 with Constitutive and Immuno-20S Proteasomes. [PDF]

Biochemistry
Wang J, Kjellgren A, DeMartino GN.
europepmc   +1 more source

Targeted Degradation of eEF2K by a Structure‐Guided PROTAC Strategy for the Treatment of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Shijun Cao, Changxin Zhong, Shilong Jiang, Yungui Li, Yang Xi, Mingxuan Xiao, Ting Jiang, Xiaoya Wan, Zonglin Chen, Xiaohui Yu, Yan Cheng   +10 more
wiley   +1 more source

miR-326 overexpression inhibits colorectal cancer cell growth and proteasome activity by targeting PNO1: unveiling a novel therapeutic intervention strategy [PDF]

Yi Fang, Yulun Wu, Xinran Zhang, Lihui Wei, Liya Liu, Youqin Chen, Daxin Chen, Nanhui Xu, Liping Cao, Jie Zhu, Mian Chen, Ying Cheng, Thomas J. Sferra, Mengying Yao, Aling Shen, Jun Peng   +15 more
openalex   +1 more source