Results 101 to 110 of about 107,280 (285)

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source

Dysregulation of CircZNF79(5) Modulates YBX1 Stability and Selective Autophagy to Drive Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
In HCC, circZNF79(5) binds to YBX1 and functions as an oncogene, recruits BRCC36 to remove K63‐linked ubiquitin chains to stabilize YBX1 protein, and promotes HCC progression via the HIF‐1 signaling pathway. Conversely, circZNF79(5) silencing activates the AMPK/mTOR pathway, inducing p62‐mediated selective autophagic degradation of YBX1.
Xueqiang Guo, Lingling Xi, Yukun Liu, Wenbao Lv, Tianzi Li, Andong Ju, Zhenlin Fan, Yaping Shen, Zhuang Qian, Weiyun Wang, Zhuo Liang, Wenjuan Song, Kaiwen Chang, Shuangping Ma, Junhe Zhang, Tao Han, Kun You, Cunshuan Xu, Lei Wang, Weisheng Guo, Wenjie Ren   +20 more
wiley   +1 more source

Skeletal Muscle HSF1 Alleviates Age‐Associated Sarcopenia and Mitochondrial Function Decline via SIRT3‐PGC1α Axis

Advanced Science, EarlyView.
Aged HSF1 muscle‐specific knockout mice show deteriorated muscle atrophy and metabolic dysfunction, while active HSF1 overexpression improves muscle function via activating SIRT3 to deacetylate both PGC1α1 and PGC1α4, which boosts mitochondrial function and muscle hypertrophy in a fiber‐type specific manner, and induces FNDC5/Irisin for tissue ...
Jun Zhang, Min Hu, Xia Wu, Mingwei Guo, Ying Ma, Jin Qiu, Siqi Wang, Yuxiang Cao, Yinzhao Zhong, Fangfang Chen, Yiwen Wang, Wei Wei, Yan Lu, Yong Zhang, Junjie Xiao, Zhenji Gan, Cheng Hu, Xinran Ma, Lingyan Xu   +18 more
wiley   +1 more source

Proteasome inhibitors: therapeutic strategy in chronic lymphoproliferative syndrome

Acta Médica del Centro, 2016
14 years ago the first results of the clinical trials phase I with bortezomib were published, the first proteasome inhibitor; its introduction into clinical practice meant an improvement in complete remission rates, of global survival and free ...
Agnerys López Sacerio, Dumeivy García Sánchez   +1 more
doaj  

Withaferin A suppresses skin tumor promotion by inhibiting proteasome-dependent isocitrate dehydrogenase 1 degradation [PDF]

, 2019
Kaiyue Xu, Chunjing Zhang, Youbo Li, Xi Xin, Lishuang Zheng, Ming Meng, Tong‐Tong Liu, Yunfeng Zhao, Wenjuan Li   +8 more
openalex   +1 more source

Supplementary Table S1 from Farnesyl and Geranylgeranyl Transferase Inhibitors Induce G₁ Arrest by Targeting the Proteasome

, 2023
Ekem T. Efuet, Khandan Keyomarsi
openalex   +1 more source

Type I Interferon Pathway Activation Disrupts Monocyte Maturation and Enhances Immune Evasion in Multiple Myeloma

Advanced Science, EarlyView.
This study shows that monocytes in multiple myeloma display an excessive interferon response, leading to transcriptional reprogramming and altered differentiation. Using single‐cell sequencing, coculture experiments, and patient samples before and after therapy, the authors demonstrate that induction treatment reduces this interferon response ...
Jian Cui, Jingwei Wang, Xiaoyun Li, Lina Wang, Xuehan Mao, Rui Lyv, Wenqiang Yan, Jingyu Xu, Jieqiong Zhou, Chenxing Du, Shuhui Deng, Mu Hao, Yan Xu, Shuhua Yi, Dehui Zou, Tao Cheng, Xin Gao, Lugui Qiu, Gang An   +18 more
wiley   +1 more source

FORMULATION DESIGN AND DEVELOPMENT OF LYOPHILZATION CYCLES FOR NOVEL FORMULATION OF PROTEASOME INHIBITOR: BORTEZOMIB [PDF]

, 2017
Yaswanth Allamneni
openalex   +1 more source

Supplementary Table 3 from Single-Nucleotide Variants and Epimutations Induce Proteasome Inhibitor Resistance in Multiple Myeloma

, 2023
Larissa Haertle, Santiago Barrio, Umair Munawar, Seungbin Han, Xiang Zhou, Michal Šimíček, Cornelia Vogt, Marietta Truger, Rafael Alonso Fernández, Maximilian Steinhardt, Julia Weingart, Renáta Šnaurová, Silvia Nerreter, Eva Teufel, Andoni Garitano-Trojaola, Matteo Da Vià, Yanira Ruiz‐Heredia, Andreas Rosenwald, Niccolò Bolli, Roman Hájek, Peter Raab, Marc S. Raab, Niels Weinhold, Claudia Haferlach, Thomas Haaf, Joaquín Martínez‐López, Hermann Einsele, Leo Rasche, K. Martin Kortüm   +28 more
openalex   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source