Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova +9 more
wiley +1 more source
Integrated approach to model distribution and assess habitat suitability of killifish species in Oman's local streams (wadis) under current and future climate conditions. [PDF]
Al Adhoobi AS +3 more
europepmc +1 more source
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau +11 more
wiley +1 more source
Implementation of a clinical decision support tool for postpartum depression: protocol for a prospective randomised clinical trial. [PDF]
Joly R, Gossey TJ, Daoud AK, Zhang Y.
europepmc +1 more source
Land Use and Land Cover Stability Across Protection Regimes in a Tropical River Basin. [PDF]
Schmitz MH +4 more
europepmc +1 more source
Objective This research article aims to describe the prevalence, associations, and health‐related quality of life (HRQoL) impact of mucocutaneous features of systemic lupus erythematosus (SLE). Methods Data from the Asia‐Pacific Lupus Collaboration cohort were analyzed (2013–2021).
Amanda M. Saracino +42 more
wiley +1 more source
Zoonotic Risk of Intestinal Parasites in Ghana's Protected Areas: A Nexus for Human-Nonhuman Primates-Dog Interactions. [PDF]
Gyarteng Mensah SS +3 more
europepmc +1 more source
Objective The study aimed to identify symptom‐based predictors of dry eye disease (DED) signs in the Sjögren's International Collaborative Clinical Alliance (SICCA) cohort. Methods We performed a retrospective analysis examining 16 ocular symptoms (most graded 0–4) and artificial tear (AT) use (graded 0–3) as predictors of DED signs (abnormal ocular ...
Pragnya R. Donthineni +7 more
wiley +1 more source
Protected Engagement Time and Related Interventions: A Scoping Review of Experience and Outcomes, and Relevance to the Australian Context. [PDF]
Hristodoulidis D, Hayward B, Searby A.
europepmc +1 more source

