Results 51 to 60 of about 478,046 (308)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

eHabitat: Large scale modelling of habitats types and similarities for conservation and management of protected areas. [PDF]

, 2014
eHabitat, which is one of the services supporting the DOPA, the Digital Observatory for Protected Areas, proposes a habitat replaceability index (HRI) which can be used for characterizing each protected area worldwide.
DUBOIS Gregoire, MARTINEZ LOPEZ JAVIER, SKOIEN JON   +2 more
core  

Identifying governance problems and solutons for forest landscape restoration in protected area landscapes

PARKS, 2019
Governance challenges – including ownership, decision-making, accountability, and sharing of costs and benefits – can impede forest landscape restoration in protected area landscapes. Understanding and addressing these challenges can improve the outcomes of forest landscape restoration.
Mansourian, Stephanie, Walters, Gretchen, Gonzales, Emily   +2 more
openaire   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Environmental context of contemporary architecture in Protected landscape area White Carpathians [PDF]

, 2013
V příspěvku je proveden rozbor tématu, zúžení jeho rozsahu na multikriteriální hodnocení obytného stavení na Kopanicích a vytýčen další postup práce.The article describes an analysis of the topic, reduction of its scope to multi-criterial evaluation ...
Hamšíková, Olga
core  

Heritage Protection Versus Individual Interests in a Post-Socialist Country: the Case of Mšeno, Czech Republic [PDF]

, 2015
Large-scale investment is routinely believed to be the main danger to urban heritage. The measures designed to sustain heritage thus traditionally focus on steering investment into respectful ways of real-estate development.
Nowotny, Vojta, Trevisan, Jitka, Wranová, Alena   +2 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Possibilities of country development from the point of wiev of tourism – an investigation in the Káli-basin (West-Hungary) [PDF]

, 1999
As the result of our study - based on representative opinionnaire -, the following suggestions were made in connection with the regional development of the Káli Basin: It would be important to prove the accommodation possibilities in the outskirts area ...
Szilassi, Péter
core  

Eco-evolutionary dynamics in fragmented landscapes [PDF]

, 2017
Peer ...
Altermatt, Astegiano, Baguette, Baguette, Baguette, Becks, Bell, Bell, Bestion, Bestion, Bitume, Blanquart, Bocedi, Bocedi, Bonduriansky, Bonte, Burgess, Carazo, Cheptou, Cheviron, Clobert, Clobert, Clobert, Cook, Cote, Crespi, Cushman, Darwin, De Meester, Delgado, DiBattista, DiBattista, Dixo, Dobzhansky, Duputié, Edelaar, Edelaar, Ellner, Evans, Fahrig, Farkas, Farkas, Farkas, Fontúrbel, Frank, Fronhofer, Fronhofer, Fukami, Fussmann, Galtier, Gandon, Gandon, Garant, Garel, Ghalambor, Gomulkiewicz, Gomulkiewicz, Guillaume, Guillaume, Gyllenberg, Haddad, Haddad, Hand, Hanski, Hanski, Hanski, Hanski, Hanski, Hanski, Hanski, Hanski, Hartl, Hassell, Hendry, Hendry, Hendry, Hendry, Henry, Higgins, Holt, Holt, Holt, Hughes, Jacob, Kawecki, Keymer, Kinnison, Kronholm, Kubisch, Laughlin, Lechowicz, Legrand, Legrand, Legrand, Leibold, Leimu, Lenormand, Lewontin, Li, Li, Lohr, Lohr, Lopez, Low-Décarie, Lynch, Manel, Massot, Meester, Morris, Mouquet, Nadeau, Nee, North, Nosil, Orsini, Orsini, Pearse, Pelletier, Perrin, Phillips, Poethke, Poethke, Poethke, Post, Ravigné, Ravigné, Riba, Richardson, Ritchie, Robert, Robinson, Rodrigues, Roissart, Ronce, Ronce, Ronce, Rousset, Räsänen, Saastamoinen, Scheiner, Schoener, Schtickzelle, Schtickzelle, Shefferson, Shine, Stapley, Tack, Taylor, Taylor, Travis, Travis, Trochet, Turner, Urban, Urban, Vellend, Walser, Wheat, Wiegand, Wiens, Wilcove, Yeaman, Yoshida, Zheng   +163 more
core   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source