Results 81 to 90 of about 517,231 (292)

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

open access: yesMolecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant   +7 more
wiley   +1 more source

Using cumulative human impact assessment to support adaptive management of the threatened species’ habitats in the Yangtze River Estuary

open access: yesGlobal Ecology and Conservation
The conflict between multiple functions of human use and habitat conservation represents an intractable challenge for environmental management. While numerous studies on marine conservation prioritize cumulative impact assessments (CIA) to tackle this ...
Wenhui Yang   +4 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

How spatial resolution mediates canopy spectral diversity as a proxy for marsh plant diversity

open access: yesEcological Informatics
Spectral reflectance variations comprehensively capture differences in the biochemical composition and morphological characteristics among plant species, making them a promising approach for monitoring and estimating plant diversity.
Yi Fu   +4 more
doaj   +1 more source

Coastal Scenic Evaluation of Continental Ecuador and Galapagos Islands: Human Impacts and Management Issues

open access: yesJournal of Marine Science and Engineering, 2020
The scenery, safety, facilities, water quality and litter quantities in coastal areas are relevant and determining elements in the choice of a tourist destination.
Carlos Mestanza-Ramón   +5 more
doaj   +1 more source

The Future of Pediatric Hematology‐Oncology Fellowship Training: Reflections on the American Board of Pediatrics Training Model

open access: yes
Pediatric Blood &Cancer, EarlyView.
Scott C. Borinstein   +11 more
wiley   +1 more source

Physician‐Scientist Pipeline for Pediatric Rheumatology: The Current Landscape and Future Perspectives

open access: yesArthritis Care &Research, EarlyView.
Over the past 50 years, the science of pediatric rheumatology has grown exponentially due to an expansion in the understanding of complex rheumatic conditions and a surge in novel targeted therapeutics. Physician‐scientists in the field of pediatric rheumatology have played major roles in these advancements that have improved the care of children ...
Ekemini A. Ogbu   +2 more
wiley   +1 more source

Application of the CZ-Globio Model in Beskydy Protected Landscape Area

open access: yesJournal of Landscape Ecology, 2023
Spatially oriented simulation models have not yet been applied to the territory of Beskydy Protected Landscape Area (PLA) to assess the state of biodiversity at a local scale. The CZ-GLOBIO model, which is adapted to the conditions of the Czech Republic,
Plánka Michal, Pechanec Vilém
doaj   +1 more source

Landscapes of the natural protected area of Vladivostok agglomeration

open access: yesSOCIALNO-ECOLOGICHESKIE TECHNOLOGII, 2018
This article is about physiographic features of the forest area of the Botanical Garden-Institute FEB RAS, which is the most important nature protected area within the Vladivostok agglomeration. As result of the field landscape researches, a landscape map was complied (with the allocation of 10 natural regions).
A.R. Pogorelov   +2 more
openaire   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

open access: yesAdvanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio   +11 more
wiley   +1 more source

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