Results 41 to 50 of about 3,316,984 (310)

Influence of common path on availability of ring network

Journal of Telecommunications and Information Technology, 2004
This paper analyses availability of the ring network which uses the path protection switching (sub-network connection protection - SNCP). Influence of the common path on the ring network availability is analyzed. Data regarding failures of optical fibre
Ivan Rados
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Protective efficacy of anti-neuraminidase monoclonal antibodies against H7N9 influenza virus infection

Emerging Microbes and Infections, 2020
The H7N9 influenza virus has been circulating in China for more than six years. The neuraminidase (NA) has gained great concern for the development of antiviral drugs, therapeutic antibodies, and new vaccines.
Fei-Fei Xiong, Xue-Ying Liu, Fei-Xia Gao, Jian Luo, Peng Duan, Wen-Song Tan, Ze Chen   +6 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Advanced Models of Personal Protective Equipment for Ground Forces Against Chemical and Biological Weapons Effects

Вестник войск РХБ защиты, 2020
Modern personal protective equipment for military personnel against the damaging factors of chemical and biological weapons (CBW) does not always allow to achieve an acceptable combination of body armor, protective helmet, respiratory and skin protective
A. A. Brusenin, V. N. Penyaz, M. A. Golyshev   +2 more
doaj   +1 more source

Glutamine supplementation attenuates bisphenol a-induced testicular toxicity in rats

Journal of Human Reproductive Sciences, 2022
Background: The induction of testicular toxicity by bisphenol A (BPA) may involve oxidative stress. Glutamine (Gln) is a rate limiter for the synthesis of glutathione (GSH), which inhibits oxidative stress.
Ben E Ehigiator, Elias Adikwu, Zellijo N Igweze   +2 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Identifying correlates of protection from Yersinia pestis on a mouse model and assessing an opportunity for their use as markers of human vaccination efficiency

Инфекция и иммунитет, 2022
In case no assessment of changes in incidence rate can be used as an indicator for effectiveness of applied live plague vaccine, it is really necessary to search for other, particularly immunological correlates for vaccine-based protection.
Svetlana N. Klyueva, S. A. Bugorkova, T. Kashtanova   +2 more
doaj   +1 more source