Results 61 to 70 of about 3,316,984 (310)

Protection and Safety Evaluation of Live Constructions Derived from the Pgm⁻ and pPCP1⁻ Yersinia pestis Strain

Vaccines, 2020
Based on a live attenuated Yersinia pestis KIM10(pCD1Ap) strain (Pgm−, pPCP1−), we attempted to engineer its lipid A species to achieve improvement of immunogenicity and safety. A mutant strain designated as YPS19(pCD1Ap), mainly synthesizing
Xiuran Wang, Amit K. Singh, Wei Sun
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Power, politics and privilege: public health at the Thai-Burma border

Forced Migration Review, 2016
Participants in a field-research methods course on refugee health at the Thai-Burma border learned that beyond the biological vectors and disease processes that contribute to human suffering, power, politics and privilege play central roles in negatively
Nikhil A Patel, Amos B Licthman, Mohit M Nair, Parveen K Parmar   +3 more
doaj  

On the canonical solution of $\protect \,\protect \,\protect \overline{\protect \!\partial }$ on polydisks

Comptes Rendus. Mathématique, 2020
We observe that the recent result of Chen–McNeal [6] implies that the canonical solution operator satisfies Sobolev estimates with a loss of $n-2$ derivatives on the polydisk $\Delta ^n$ and particularly is exact regular on $\Delta ^2$.
Jin, Muzhi, Yuan, Yuan
openaire   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Electromagnetic cloak design with mono-objective and bi-objective optimizers: seeking the best tradeoff between protection and invisibility

EPJ Applied Metamaterials
We revisit the design of cloaks, without resorting to any geometric transform. Cancellation techniques and anomalous resonances have been applied for this purpose. Instead of a deductive reasoning, we propose a novel mono-objective optimization algorithm,
Aznavourian Ronald, Demesy Guillaume, Guenneau Sébastien, Marot Julien   +3 more
doaj   +1 more source

LOI N°9/001 DU 10 JANVIER 2009 PORTANT PROTECTION DE L’ENFANT : ENTRE PRÉSOMPTION D’IRRESPONSABILITÉ AVÉRÉE ET RESPONSABILITÉ PÉNALE MAQUILLÉE DU MINEUR [PDF]

Cahiers Africains des Droits de l’Homme et de la Démocratie ainsi que du Développement Durable, 2022
Le mineur et le droit pénal reste est une question qui divise plus d’une personne en RDC. La grande question est de savoir si l’enfant peut ou non répondre pénalement au regard de la législation en vigueur. A n’en point douter, la loi portant protection
Mechack MANDEFU MUELA, Jean-Pierre KABEMBA KAPENGA   +1 more
doaj  

Putting the ‘Protection’ in ‘Temporary Protection Visa’ [PDF]

Bond Law Review, 2016
This article considers the legality of Australia’s second TPV regime (introduced by the Migration and Maritime Powers Legislation Amendment (Resolving the Asylum Legacy Caseload) Act 2014 (Cth)) under the Convention Relating to the Status of Refugees and accompanying International Human Rights Law instruments.
openaire   +4 more sources

Online Personal Data Processing and EU Data Protection Reform. CEPS Task Force Report, April 2013 [PDF]

, 2013
This report sheds light on the fundamental questions and underlying tensions between current policy objectives, compliance strategies and global trends in online personal data processing, assessing the existing and future framework in terms of effective ...
Luchetta, Giacomo, Irion, Kristina
core  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source