Results 81 to 90 of about 7,937,209 (346)

Translating proprietary protection setting data into standardized IEC 61850 format for protection setting validation [PDF]

open access: yes, 2014
For smart grid development, one of the key expectations is that the data should be accessible to and readily interpreted by different applications. Presently, protection settings are represented using proprietary parameters and stored in various file ...
Blair, Steven Macpherson   +5 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Copyright, Potential Markets, and the User Interface: Defining the Scope of the Limited Monopoly [PDF]

open access: yes, 1992
Although most court cases involving copyright protection of the user interface appear to have been decided correctly on their facts, the language of the decisions has left uncertainty as to the scope of ...
Daubert, Todd D.
core   +2 more sources

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Parental participation in statutory child protection intervention in Scotland [PDF]

open access: yes, 2016
In recent years there has been an increasing interest in understanding parental participation in the processes that characterise statutory child protection intervention.
Jackson, Sharon   +2 more
core   +4 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Electromagnetic cloak design with mono-objective and bi-objective optimizers: seeking the best tradeoff between protection and invisibility

open access: yesEPJ Applied Metamaterials
We revisit the design of cloaks, without resorting to any geometric transform. Cancellation techniques and anomalous resonances have been applied for this purpose. Instead of a deductive reasoning, we propose a novel mono-objective optimization algorithm,
Aznavourian Ronald   +3 more
doaj   +1 more source

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