Results 71 to 80 of about 13,620,416 (309)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
SEA LEVEL RISE AND EQUITY WEIGHTING [PDF]
Using the FUND model, an impact assessment is conducted over the 21st century for rises in sea level of up to 2-m/century and a range of national socio-economic scenarios.
Richard S.J. Tol +2 more
core
Child Protection and PracticeBackground: In Australia, children and young people in out-of-home care (OOHC) face high rates of complex mental health challenges, yet no systemic framework exists to address their needs effectively.
Lottie G. Harris +2 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Readiness to implement the action plan to strengthen regional cooperation on social protection : Mongolia [PDF]
, 2023 Governments in Asia and the Pacific are increasingly recognizing social protection as a key policy instrument to build productive, protected and healthy populations. In 2020, ESCAP member States endorsed the Action Plan to Strengthen Regional Cooperation
Government of Mongolia. Ministry of Labour and Social Protection +1 more
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
The Economic Impact of Substantial Sea-Level Rise [PDF]
Using the FUND model, an impact assessment is conducted over the 21st century for rises in sea level of up to 2-m/century and a range of socio-economic scenarios downscaled to the national level, including the four SRES storylines.
Richard S.J. Tol +3 more
core
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
AN ANALYSIS STUDY OF PROTECTION LEVELS AT A LOW LATITUDE INDIAN STATION FOR THE GAGAN [PDF]
Journal of Engineering Science and Technology, 2017 GPS-aided Geo-augmented Navigation (GAGAN) provides an improvement in accuracy and integrity to Global Navigation Satellite System (GNSS) signals for navigation and positioning applications in India.
SRIDHAR M. +2 more
doaj