Results 111 to 120 of about 2,531,538 (311)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

A model for integrating social protection measures with TB control in Pakistan. [PDF]

Int J Tuberc Lung Dis, 2023
Habib SS, Uzair M, Dhanwani A, Sohail K.
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Ensuring cybersecurity of FPGA as a service with the use of penetration testing of components

Радіоелектронні і комп'ютерні системи
The subject of study in this article is modern penetration testing technologies, in which the test object is the implementation of a service based on a platform using Field Programmable Gate Array (FPGA) resources.
Artem Tetskyi, Artem Perepelitsyn, Oleg Illiashenko, Olga Morozova, Dmytro Uzun   +4 more
doaj   +1 more source

Fire risk assessments and fire protection measures for wind turbines: A review. [PDF]

Heliyon, 2023
You F, Shaik S, Rokonuzzaman M, Rahman KS, Tan WS.   +4 more
europepmc   +1 more source

Data availibility for the fisheries impact assessment of the FIMPAS project [PDF]

The project Fisheries Measures in Protected Areas (FIMPAS) aims to introduce fisheries measures in the marine Natura 2000 sites within the Exclusive Economic Zone of the Dutch part of the North Sea by the end of 2011. The FIMPAS project covers three such
Asjes, J., Bemmelen, R.S.A., van, Craeymeersch, J.A.M., Deerenberg, C.M., Hal, R., van, Jak, R.G., Polanen-Petel, T., van, Quirijns, F.J., Scheidat, M., Teal, L.R.   +9 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Harmfulness of beet nematode in table and fodder beet crops

Карантин і захист рослин
Goal. To determine the degree of harmfulness of the beet cyst nematode (Heterodera schachtii Schmidt) in table (Beta vulgaris L. var. conditiva) and fodder (Beta vulgaris L. var.
К. Kalatur
doaj   +1 more source

Radiation protection measures during endourological therapies. [PDF]

Asian J Urol, 2023
Tzelves L, Juliebø-Jones P, Manolitsis I, Bellos T, Mykoniatis I, Berdempes M, Markopoulos T, Lardas M, Zeeshan Hameed BM, Angelopoulos P, Pietropaolo A, Somani B, Varkarakis I, Skolarikos A.   +13 more
europepmc   +1 more source

GUARDIANSHIP - PROTECTIVE MEASURE

Social Sciences and Education Research Review
The way in which personal protection measures are regulated by civil law reflects in all legal systems the degree of concern of the state power to provide the necessary legal framework so that persons who are vulnerable for various reasons can take part in the civil circuit without being prejudiced.
openaire   +2 more sources