Results 121 to 130 of about 367,409 (312)

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Analysis of the legal and organizational framework for ensuring the security of personal data

Современная наука и инновации
The paper analyzes the features of the application of the legal framework for ensuring the security of PD, as well as reveals the essential organizational aspects of planning a PD protection system in an organization.
E. A. Ovchinnikova, E. A. Semenova, V. V. Tsapleva   +2 more
doaj   +1 more source

Protection of personal data in the decision-making practice of the Office for Personal Data Protection

, 2023
Protection of personal data in the decision-making practice of the Office for Personal Data Protection Abstract This work is devoted to the right to personal data protection, which is constitutionally protected in the Czech Republic. According to Article
Lipanová, Kateřina
core  

Ethical Precision in Nanoscale Brain Interfacing

Advanced Science, EarlyView.
As brain interfaces approach the nanoscale, precision no longer only measures—it knows, predicts, and potentially reshapes the mind. This work argues that traditional ethics fails under such conditions and proposes a shift toward continuous, operation‐based governance using the recovery–discovery framework to track, constrain, and responsibly steer ...
Guilherme Wood
wiley   +1 more source

Bioadhesive Hydrogel With Polyphenol‐Armored Nanogene Rejuvenates Chondrocyte Senescence for Aged Osteoarthritis Therapy

Advanced Science, EarlyView.
An adhesive hydrogel depot with polyphenol‐armored nanogenes is developed for treating aged osteoarthritis. This system maintains miR‐140 bioactivity, prolongs its intra‐articular retention, and enhances transfection into chondrocytes, leading to the downregulation of senescence‐associated pathways.
Liwei Yan, Runze Yang, Ting Zhou, Tianhao Xu, Yongqi Li, Yuelin Hu, Minghao Ge, Lei Zhang, Xiong Lu, Chaoming Xie, Weili Fu   +10 more
wiley   +1 more source

The Problem of Trans-Border Information Flows in the Protection of Personal Information

Potchefstroom Electronic Law Journal
Cross-border transfers of personal information have become an important integrant of international trade, global economic activities enabler and a component of digital services driver, however, they are faced with the limitations of cross-border ...
Mthuthukisi Malahleka
doaj   +1 more source

ACLY‐Driven Metabolic Reprogramming Promotes Histone Acetylation and Inflammation‐Associated Fibrosis in Chronic Kidney Disease

Advanced Science, EarlyView.
This study reveals a citrate–ACLY–H3K27ac metabolic–epigenetic axis driving inflammatory gene activation and kidney fibrosis, highlighting ACLY inhibition as a potential therapeutic strategy for chronic kidney disease (CKD). ABSTRACT The mechanisms by which metabolic stress drives epigenetic dysregulation and fibrosis in chronic kidney disease (CKD ...
Chunxiu Du, Dhanunjay Mukhi, Lingzhi Li, Chenyu Li, Siyu Pan, Bernhard Dumoulin, Eunji Ha, Lakshmi P Kolligundla, Yanjuan Hou, Jonathan Levinsohn, Chaelin Kang, Konstantin Adrian Klötzer, Junnan Wu, Samer Mohandes, Kathryn E Wellen, Katalin Susztak   +15 more
wiley   +1 more source

CONSTITUTIONALSM - REFORM ON DATA PROTECTION LAW AND HUMAN RIGHTS [PDF]

The purpose of this paper is to address one of the most Fundamental Freedom and Human Rights the protection of privacy, particularly under the provisions of the European Convention on Human Rights as interpreted by the Strasbourg institutions and by ...
Rezana BALLA
core  

Highly Efficient and Environmentally Stable Radiative Cooling Fabric: Integrating Photoluminescence and Hierarchical Core–Shell Fibers

Advanced Science, EarlyView.
A scalable radiative cooling fabric engineered with a multi‐layer assembly core–shell structure and integrated photoluminescent materials is reported. The fabric exhibits remarkable environmental stability, including UV resistance, mechanical durability, hydrophobicity, stain resistance, thermal stability, and flame retardancy, demonstrating its ...
Hongtao Liu, Hui Li, Yining Wang, Wei Sun, Zhuan Chen, Yongping Hou, Yongmei Zheng, Xuejian Chen, Bin Yu   +8 more
wiley   +1 more source

Personal Data Protection in Digital Business Based on the Law on Personal Data Protection

International Journal of Research in Social Science and Humanities
The development of information technology drives the growth of digital businesses in Indonesia, which directly increases the activities of collecting, processing, and storing consumer personal data. However, on the other hand, the rampant misuse and leakage of personal data pose a serious threat to the privacy rights of the public.
Dony Dwi Wijayanto, Kadek Wiwik Indrayanti, Diah Ayu Wisnu W   +2 more
openaire   +2 more sources