Results 91 to 100 of about 420,436 (299)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Mils Complete Separation Platform Protection Profile

, 2017
This paper considers the applicability of Common Criteria (CC) to ‘minimally necessary (complete) separation platform’ comprising underlying hardware and separation (virtualisation) kernel and shares our experience in modelling the security policy for the MILS separation platform.
Igor Furgel, Viola Saftig
openaire   +2 more sources

Big Darby Creek Case Study: A Profile of Watershed Threats and Protection in a Midwest Landscape

, 2000
37 pages; available for download at the link below.This report presents the results of a 1996 inquiry by an EPA team into the circumstances and events that affected the natural environment of Big Darby Creek and its supporting watershed, just west of ...
United States Environmental Protection Agency Office of Water
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

The effects of patent term extension on new drug patent protection in China, Europe, and the United States

Medicine in Drug Discovery
Background: China has recently introduced patent term buchang (PTB) for new drugs. This study presents a systematic profile for China’s PTB, European SPC, and the U.S. PTE for new drug protection.
Hai-Long Zhang, Yongxia Li
doaj   +1 more source

Compliance of RIES to the Proposed e-Voting Protection Profile

, 2007
The RIES-KOA e-voting system was used in the Netherlands as an additional system for the elections by expatriates for the Tweede Kamer (roughly: the Dutch House of Commons) elections in 2006. Although the system has been used in other elections in the Netherlands as well, there have been few independent evaluations of the system.
Jonker, Hugo, Volkamer, Melanie
openaire   +6 more sources

Separation Kernel Protection Profile Revisited: Choices and Rationale [PDF]

, 2010
A variety of critical decisions were made during the development of the U.S. Government Protection Profile for Separation Kernels in Environments Requiring High Robustness (the SKPP); in addition several errata that have come to light since its ...
Levin, Timothy E., Nguyen, Thuy D., Irvine, Cynthia E., McEvilley, Michael   +3 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Biomolecular relationship of whole protein of Mannheimia haemolytica, Pasteurella trehalosi and Pasteurella multocida of sheep

Journal of Veterinary Medical Research, 2010
P. multocida contains one or more antigenic determinant of different proportions responsible for partial protection offered by the heterologous serovars. SDS-PAGE analysis of the whole protein profile prepared from sheep local isolates of P.
Amal M. El-Sawah, Eman M. El-Rawy
doaj  

An mRNA-based seasonal influenza vaccine in adults: Results of two phase 3 randomized clinical trials and correlate of protection analysis of hemagglutination inhibition titers

Human Vaccines & Immunotherapeutics
The safety, immunogenicity, and efficacy of the original formulation of the investigational mRNA-1010 vaccine for seasonal influenza were investigated in two randomized, active-controlled, phase 3 trials in adults (NCT05415462 and NCT05566639), and the ...
Boris Kandinov, Mieke Soens, Wenmei Huang, Conrado Llapur, David Ensz, Brandon Essink, Carlos Fierro, Jignesh Vakil, Alicia Pucci, Jia Guo, Sinead Rudden, Kristi Hall, Bryony Hicks, Kristin Schaefers, Honghong Zhou, Chong Ma, Lingyi Zheng, Andrei Avanesov, Yoonyoung Park, Evelyn Du, Jacqueline Miller, Jintanat Ananworanich, Raffael Nachbagauer   +22 more
doaj   +1 more source