Results 81 to 90 of about 420,436 (299)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Experimental Study of the Scour Regimes Downstream of an Apron for Intermediate Tailwater Depth Conditions

Journal of Applied Fluid Mechanics, 2014
The local scour of a non-cohesive bed due to a 2-D submerged horizontal jet is investigated experimentally in presence of a protection apron. Previous researches conducted without protection apron demonstrate that, when the tailwater depth is either deep
Paolo Espa, Stefano Sibilla
doaj  

Profile of dementia in rural area of Indonesia [PDF]

, 2020
and Figures Introduction: Dementia is the ability degradation of remembering and thinking that interrupts one's daily activity, which will be an additional burden to the elderly.
Azimatul Karimah, Azimatul, Kartika Wensdi Renantriandani, Kartika, Jovian Philip Swatan, Jovian, Qurrota Ayuni Novia Putri, Qurrota, A ' La Illiyine, A ' La, Farida Zahira, Farida, Siti Ermawati, Siti, Vivi Permata Sari, Vivi, Emildha Dwi, Emildha, Nurul Hafizah, Nurul, Edi Nurcahyo, Edi, Andika Hilman Pramudita, Andika, Aditya Putra, Aditya, Margarita M. Maramis, Margarita   +13 more
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A profile of border protection in Egypt : an effective rate of protection approach adjusting for energy subsidies [PDF]

This study examines recent effective rates of protection across the Egyptian economy, using an ad valorem price wedge introduced by nontariff barriers and energy subsidies, and compares today's effective rates of protection with those of a decade ago ...
Foster, William, Valdes, Alberto
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

High Robustness Requirements in a Common Criteria Protection Profile [PDF]

, 2006
The development of a Common Criteria protection profile for high-robustness separation kernels requires explicit modifications of several Common Criteria requirements as well as extrapolation from existing (e.g., medium robustness) guidance and decisions.
Levin, Timothy E., Nguyen, Thuy D., Irvine, Cynthia E.   +2 more
core  

Development of a Protection Profile Module for Encryption Key Management Components

, 2023
Development of a Protection Profile Module for Encryption Key Management ...
Md Zahidul Islam (13348095), Md Rafiqul Islam (11696579), Hin Chan (13348089), Chang-Tsun Li (13063659), Warren Armstrong (13348098), Nan Sun (788187)   +5 more
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source