Results 61 to 70 of about 420,436 (299)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

ANALYSIS OF SUPP LY LOGISTICS OF PRIVATE AGRICULTURAL FARMS IN THE ARTIFICIALFERTILIZERS [PDF]

Annals of the Polish Association of Agricultural and Agribusiness Economists, 2018
The aim of the work was to assess the supplying process of production means in private farms withdiversified area and profile production (mixed production – cattle breeding and cereal cultivation, andone-way production – cereal cultivation).
Krzysztof Pakuła, Beata Kuziemska, Marcin Becher, Aleksandra Kiepuszewska   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Gender‐biased kidney damage in mice following exposure to tobacco cigarette smoke: More protection in premenopausal females

Physiological Reports, 2020
Multiple clinical studies documented renal damage in chronic cigarette smokers (CS) irrespective of their age and gender. Premenopausal female smokers are known to exert a certain cardiovascular and renal protection with undefined mechanisms.
Abdullah Kaplan, Emna Abidi, Nada J. Habeichi, Rana Ghali, Hiam Alawasi, Christina Fakih, Kazem Zibara, Firas Kobeissy, Ahmad Husari, George W. Booz, Fouad A. Zouein   +10 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

C5 inhibition restores B cell homeostasis and humoral immunity in CHAPLE disease patientsC5 inhibition restores B cell homeostasis in CHAPLE disease [PDF]

Journal of Human Immunity
CD55 deficiency drives complement hyperactivation, severe gastrointestinal pathology, and disrupted B cell homeostasis. Our findings show that complement inhibition in CHAPLE disease restores serum immunoglobulin levels, re-establishes a normal B cell ...
Azzeddine Tahiat, Reda Belbouab, Abdelghani Yagoubi, Sofija Buta Panov, Lorenzo Cuollo, Kamel Djenouhat, Dusan Bogunovic   +6 more
doaj   +1 more source

Pre-clinical efficacy and safety of experimental vaccines based on non-replicating vaccinia vectors against yellow fever. [PDF]

PLoS ONE, 2011
BACKGROUND: Currently existing yellow fever (YF) vaccines are based on the live attenuated yellow fever virus 17D strain (YFV-17D). Although, a good safety profile was historically attributed to the 17D vaccine, serious adverse events have been reported,
Birgit Schäfer, Georg W Holzer, Alexandra Joachimsthaler, Sogue Coulibaly, Michael Schwendinger, Brian A Crowe, Thomas R Kreil, P Noel Barrett, Falko G Falkner   +8 more
doaj   +1 more source

Soil Profile Analytical Database for Europe (SPADE): Reconstruction and Validation of the Measured Data (SPADE/M) [PDF]

, 2006
The Soil Profile Analytical Database of Europe of Measured profiles (SPADE/M) was created to provide a common structure for storing harmonized information on typical soil profile properties of European soils.
Jones, Robert J. A., Hiederer, Roland, Daroussin, J.   +2 more
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