Results 41 to 50 of about 420,436 (299)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Complementarity determining regions in SARS-CoV-2 hybrid immunity

Frontiers in Immunology, 2023
Pre-vaccination SARS-CoV-2 infection can boost protection elicited by COVID-19 vaccination and post-vaccination breakthrough SARS-CoV-2 infection can boost existing immunity conferred by COVID-19 vaccination.
Glynis Frans, Doreen Dillaerts, Tom Dehaemers, Jan Van Elslande, Jonas De Leeuw, Lise Boon, Wim Maes, Nico Callewaert, Bas Calcoen, Lina Ancheva, Maaike Cockx, Nick Geukens, Kusay Arat, Rita Derua, Rita Derua, Pieter Vermeersch, Pieter Vermeersch, Sebastien Christian Carpentier, Xavier Bossuyt, Xavier Bossuyt   +19 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

CITIZENS HEALTH PROTECTION BEHAVIOUR AGAINST VECTOR BORN DISEASES IN GREECE: THE CASE OF XANTHI [PDF]

Buletin ştiinţific: Universitatea din Piteşti. Seria Ştiinţe Economice, 2016
During the period of 2012-2014 a West Nile Virus (WNV) outbreak occurred in the Regional District of Xanthi in Greece. As the self-protection measures are the most important for securing the public health this paper aims to explore the citizens buying ...
Lambros TSOURGIANNIS, Despoina CHATZIPANAGIOTOU, Loukas GEORGIOU, Kyriakos PAVLIDIS, Valentin DISLIAN   +4 more
doaj  

Anxiety profiles and protective factors: A latent profile analysis in children [PDF]

Personality and Individual Differences, 2018
The current study investigated the presence of different anxiety profiles in schoolchildren in order to understand whether Mathematics and Test Anxiety are a manifestation of a general form of anxiety, or the expression of specific forms of anxiety. Moreover, we also examined the influence of personal protective factors. The results of a latent profile
Mammarella, Irene C., DONOLATO, ENRICA, Caviola, Sara, Giofrè, David   +3 more
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The Dynamics of Interleukin-10-Afforded Protection during Dextran Sulfate Sodium-Induced Colitis

Frontiers in Immunology, 2018
Inflammatory bowel disease encompasses a group of chronic-inflammatory conditions of the colon and small intestine. These conditions are characterized by exacerbated inflammation of the organ that greatly affects the quality of life of patients ...
Ana Cardoso, Ana Cardoso, Ana Cardoso, Ana Cardoso, Ana Cardoso, Ana Cardoso, Ana Cardoso, Antonio Gil Castro, Antonio Gil Castro, Ana Catarina Martins, Ana Catarina Martins, Guilhermina M. Carriche, Guilhermina M. Carriche, Valentine Murigneux, Valentine Murigneux, Isabel Castro, Isabel Castro, Ana Cumano, Ana Cumano, Ana Cumano, Paulo Vieira, Paulo Vieira, Paulo Vieira, Margarida Saraiva, Margarida Saraiva   +24 more
doaj   +1 more source

Smart Meter Protection Profile [PDF]

, 2014
There have been great advancements in deployment and regulations of Smart Grid Systems all around the world throughout the late years. Following these advancements, Turkey is taking some actions to get the advantages of this technology.
Güler, Neslihan, Müftüoğlu, Zümrüt, Öztemur, Muhammet   +2 more
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source