Results 121 to 130 of about 5,762,867 (344)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Fault Tree-Based Reliability Assessment of a 132-kV Transmission Line Protection Scheme [PDF]

, 2013
The reliability of a power system network depends greatly on the performance of the protection system. Improving the reliability of the protection scheme of the transmission lines will enhance the overall reliability of the power system network.
Awelewa, A. A., Katende, J., Odigwe, I. A., Samuel, I. A.   +3 more
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Design of an Improved Protection Scheme of Mine Zone Selective Interlocking

Gong-kuang zidonghua, 2012
For problems that response time of underground integrated protection switches is long and uncertain because the switches are coming from different manufacturers and have different models, the paper proposed an improved protection scheme based on analysis
HUANG Cui-bai, TANG Bai-shan
doaj  

Enhanced pilot protection scheme for half-wavelength transmission line based on the conservation of traveling wave energy

International Journal of Electrical Power & Energy Systems
The half-wavelength transmission system is a viable technology for long-distance and large-capacity power transmission. It can safely and efficiently transmit a large amount of clean energy to remote load centers.
Yutao Tang, Hongchun Shu, Yue Dai, Yiming Han   +3 more
doaj   +1 more source

GLPS: A Geohash-Based Location Privacy Protection Scheme. [PDF]

Entropy (Basel), 2023
Liu B, Zhang C, Yao L, Xin Y.
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Survivability Protection in TWDM Optical Access Network with Dynamic Wavelength Scheduling

Dianxin kexue, 2015
It is a key technical problem to locate failure correctly and perform protection switching for strong survivability in time and wavelength division multiplexing（TWDM）optical access network with dynamic wavelength scheduling. To solve the above problem, a
Xintian Hu, Zhiguo Zhang, Xue Chen
doaj   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source