Results 121 to 130 of about 2,054,708 (251)
Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis
FEBS Open Bio, EarlyView.Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto +14 more
wiley +1 more source
Biennial report of the State Land Agent to the Governor of Oregon.
, 1897 State land agent : T.W. Davenport, 1895-1899; L.B. Greer, 1899-1902; Oswald West, 1902-1907; Chas. V. Galloway, 1907-1909; Peter Applegate, 1909-1911; T.A.
Oregon. State Land Board. +1 more
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FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Protective measurements and relativity of worlds [PDF]
, 2013 It is a fundamental and widely accepted assumption that a measurement result exists universally, and in particular, it exists for every observer, independently of whether the observer makes the measurement or knows the result.
Gao, Shan, Shan Gao
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Functionalization of ZnAl-Layered Double Hydroxide with Ensulizole and Its Application as a UV-Protective Agent in a Transparent Polymer Coating. [PDF]
Molecules, 2023 Melánová K +6 more
europepmc +1 more source
In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans
FEBS Open Bio, EarlyView.In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller +3 more
wiley +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
A formal framework for the semantics of agent interactions
, 2005 Although informative, the semantic definition proposed for the most standard agent communication language (FIPA ACL 1997) is complicated and contentious, while published inter-action protocols (IPs) tend to be ambiguous, incomplete, and unverified with ...
Jennings, N. R. +5 more
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Thiamine as a peripheral neuro-protective agent in comparison with N-acetyl cysteine in axotomized rats. [PDF]
Iran J Basic Med Sci, 2023 Mousavinezhad-Moghaddam M +4 more
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre‐existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high‐risk population.
Michał Borończyk +10 more
wiley +1 more source