Results 321 to 330 of about 469,365 (378)

Targeted STING Activation Using Modified Ultrasound‐Responsive Microbubbles Enhances Immune Checkpoint Blockade Against Melanoma

Advanced Science, EarlyView.
This study explores the use of ultrasound contrast agents loaded with Stimulator of Interferon Genes (STING) agonists as an approach to activate the body's immune system against cancer. Termed Microbubble‐assisted UltraSound‐guided Immunotherapy of Cancer (MUSIC), this strategy effectively inhibits tumor growth and improves survival in mouse models of ...
Sina Khorsandi, Kristin Huntoon, Yifan Wang, Adam Woodward, Abin Antony, Connor Endsley, Nazia Hafeez, Jared L. Edwards, Nicole McCuen, Prasanna G. Alluri, Betty Y.S. Kim, Wen Jiang, Jacques Lux   +12 more
wiley   +1 more source

PRMT1‐Mediated SWI/SNF Complex Recruitment via SMARCC1 Drives IGF2BP2 Transcription to Enhance Carboplatin Resistance in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
PRMT1 drives carboplatin resistance and tumor progression in head and neck squamous cell carcinoma (HNSCC) through a novel, methyltransferase‐independent mechanism. It recruits the SWI/SNF complex to activate IGF2BP2, promoting tumor growth and carboplatin resistance. PBX2 upregulates PRMT1, reinforcing this pathway. This study uncovers a non‐catalytic
Shixian Liu, Wentao Zhang, Weiwei Liu, Zhao Ding, Ruijing Zhang, Yuefeng Han, Zihao Niu, Mengdie Zhang, Hui Li, Dapeng Li, Zixi Wang, Jie Peng, Yu Wu, Yanxun Han, Zihui Xie, Jing Wu, Liang Qin, Zhongdong Hu, Xu Chen, Yunlong Hu, Yehai Liu, Shiyin Ma, Xiaojun Zha   +22 more
wiley   +1 more source

Molecular cloning of a protective antigen of schistosomes [PDF]

Nature, 1987
The complementary DNA sequence encoding the Mr 28,000 antigen of Schistosoma mansoni has been isolated and expressed in Escherichia coli. Experimental vaccination of rats, hamsters and monkeys with a recombinant fusion protein induces a strongly cytotoxic antibody response.
Dominique Dreyer, Jean-Pierre Lecocq, André Capron, Monique Capron, Paul Sondermeyer, D. Carvallo, Raymond J. Pierce, Jean-Marc Balloul, J. M. Grzych   +8 more
openaire   +2 more sources

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Antigenic: An improved prediction model of protective antigens

Artificial Intelligence in Medicine, 2019
An antigen is a protein capable of triggering an effective immune system response. Protective antigens are the ones that can invoke specific and enhanced adaptive immune response to subsequent exposure to the specific pathogen or related organisms. Such proteins are therefore of immense importance in vaccine preparation and drug design.
Md. Khaledur Rahman, Mohammad Kaykobad, Sanjay Saha, M. Sohel Rahman, M. Saifur Rahman   +4 more
openaire   +2 more sources

Hsp70 in parasites: as an inducible protective protein and as an antigen [PDF]

Experientia, 1994
The heat shock (HS) response is a general homeostatic mechanism that protects cells and the entire organism from the deleterious effects of environmental stresses. It has been demonstrated that heat shock proteins (HSP) play major roles in many cellular processes, and have a unique role in several areas of cell biology, from chronic degenerative ...
MARESCA, Bruno, G. S. Kobayashi
openaire   +3 more sources

Nematode antigens in protection, diagnosis and pathology

Veterinary Immunology and Immunopathology, 1987
A thorough study of parasite antigens is a prerequisite for control programmes based on protection by vaccination, accurate serodiagnosis and perhaps immune modulation to diminish pathological sequelae. Stage specific surface secreted and somatic antigens may be of particular value in proceeding towards these goals.
R. M. E. Parkhouse, Z. Cabrera, William Harnett, N. M. Almond   +3 more
openaire   +3 more sources

Protective antigens in brucellosis

Annales de l'Institut Pasteur / Microbiologie, 1987
International ...
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Localization of protective antigens in Trighostrongylus colubriformis

International Journal for Parasitology, 1991
In order to localize protective antigens in Trichostrongylus colubriformis, adult worms were microdissected and the capacity of worm tissues to protect guinea pigs against infection examined. The results suggest that T. colubriformis protective antigens are widely distributed in the body and are not concentrated in the intestine or glandular structures.
T.L.W. Rothwell, Nicholas C. Sangster
openaire   +3 more sources

Protective Cellular Antigen of Clostridium chauvoei

American Journal of Veterinary Research, 1980
SUMMARY Cellular antigens of Clostridium chauvoei, strain IRP-128, were demonstrated to be important in induction of immunity against this bacterium in guinea pigs. At least one major component of the cellular antigen complex was heat-labile. Acid extraction of the bacterial cells, followed by selective purification for flagella, led to the preparation
J R, Stevenson, K A, Stonger
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Characterization of protective antigens and the protective immune response

Veterinary Microbiology, 1993
The protective immune response to a vaccine may be due to the presence of circulating antibody (humoral immunity), the actions of sensitized T-lymphocytes (cell-mediated immunity), the presence of secretory IgA on mucosal surfaces (mucosal immunity), or a combination of these factors. In general, humoral immunity is felt to be particularly important in
openaire   +3 more sources