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Finding Protective Bacterial Antigens
2012Current vaccine development efforts are mainly focused on opportunistic pathogens that are frequent colonizers and have complex pathogenesis and interaction with the human host. Therefore, more sophisticated and comprehensive vaccine development approaches have to be considered than for strictly pathogenic bacteria with well-defined virulence ...
Eszter Nagy, Guido Grandi
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Protective Antigens of Vibrio Cholerae
1989The disease cholera in the epidemic form is mainly caused by the gram- negative bacterium Vibrio cholerae, belonging to the 01 serovar. The or-ganism also exists in two serotypes (Inaba and Ogawa) and biotypes (clas-sical and El Tor). It is known that the diarrheagenic syndrome in cholera patients is primarily caused by an enterotoxin (cholera toxin ...
Asoke C. Ghose, Chiranjib Dasgupta
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Specificity of Trichostrongylus colubriformis Protective Antigens
The Journal of Parasitology, 1981FIGURE 1. Circulating antigens in the serum of a cynomolgus macaque infected with tetrathyridia in M. corti. Center well (c) contains RAS/E; wells 1 to 3 contain serum from host number 1 (splenectomized) at days 91, 98, 105 p.i.; wells 4 to 6 contain serum from host number 2 (intact) for the same time periods.
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Expression Cloning of a Protective Leishmania Antigen
Science, 1995Parasite-specific CD4 + T cells have been shown to transfer protection against Leishmania major in susceptible BALB/c mice. An epitope-tagged expression library was used to identify the antigen recognized by a protective CD4 + T cell clone.
Thierry Coppola +8 more
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Acid induced unfolding of anthrax protective antigen
Biochemical and Biophysical Research Communications, 2003Acidic pH plays an important role in the membrane insertion of protective antigen (PA) of anthrax toxin leading to the translocation of the catalytic moieties. The structural transitions occurring in PA as a consequence of change in pH were investigated by fluorescence and circular dichroism measurements.
Pradeep K. Gupta +6 more
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A HEAT STABLE PROTECTIVE STAPHYLOCOCCAL ANTIGEN
Australian Journal of Experimental Biology and Medical Science, 1960SUMMARYA strain of staphylococci, chosen for the very marked enhancement by mucin of its intraperitoneal virulence to mice, was cultured in sloppy agar.The supernatant fluids obtained were of low toxicity and were highly potent as active immunizing agents in mice against lethal intraperitoneal challenge by the homologous strain in mucin suspension. The
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Onchocerca antigens in protection, diagnosis and pathology.
Ciba Foundation symposium, 1987Characterization of the immune response to Onchocerca volvulus is important for the diagnosis, control and understanding of the disease it causes. The antibody response to surface, secreted and somatic antigens of the worm has therefore been examined at an individual immunoglobulin (Ig) class level, by using a panel of different human sera.
William Harnett +2 more
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Hymenolepis diminuta: The origin of protective antigens
Experimental Parasitology, 1982Abstract Mice were infected orally with 1,6, or 30 cysticercoids of Hymenolepis diminuta . These were allowed to develop for different periods of time before elimination with anthelminthic, thus exposing the hosts to antigens from the prestrobilate, early strobilate, or fully strobilate worms.
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A Soluble Protective Antigen of Trypanosoma brucei
Nature, 1960Trypanosoma brucei in quantities sufficient for antigenic analysis was obtained by harvesting the blood of rats on the third day of infection by the protozoon, when the fulminating parasitaemia is at its height. The trypanosomes were separated from the blood by centrifugation and the resulting mash was preserved by freeze drying.
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Characterization of a new protective antigen of Streptococcus canis
Veterinary Research Communications, 2010Streptococcus canis (S. canis), a lancefield group G streptococcus, is an opportunistic pathogen mainly found in dogs and cats. The study on pathogenesis and protective immune mechanism of S. canis is not clear. A new streptococcal protective antigen (SPA) was first identified from a genomic library of S. canis. SPA of S. canis (SPASc) contained a 1224-
Benqiang Li +3 more
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