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Anthrax Protective Antigen: Prepore-to-Pore Conversion
Biochemistry, 1999PA(63), the active 63 kDa form of anthrax protective antigen, forms a heptameric ring-shaped oligomer that is believed to represent a precursor of the membrane pore formed by this protein. When maintained at pH >/=8.0, this "prepore" dissociated to monomeric subunits upon treatment with SDS at room temperature, but treatment at pH
Christopher J. Miller +2 more
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Characterization of Membrane Translocation by Anthrax Protective Antigen
Biochemistry, 1998Solving the crystallographic structure of the ring-shaped heptamer formed by protective antigen (PA), the B moiety of anthrax toxin, has focused attention on understanding how this oligomer mediates membrane translocation of the toxin's A moieties. We have developed an assay for translocation in which radiolabeled ligands are bound to proteolytically ...
Pål Ø. Falnes +4 more
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Protective antigens of rodent and hum an bloodstage malaria
Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1984Bloodstage malaria parasites are antigenically complex, but individual antigens can be identified and analysed using monoclonal antibodies. Two monoclonal antibodies that recognize a 235000 molecular mass Plasmodium yoelii rhoptry protein provide some protection when injected into mice against a challenge infection.
Anthony A. Holder, Robert R. Freeman
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Cloning of the protective antigen gene of Bacillus anthracis
Cell, 1983The tripartite protein toxin of Bacillus anthracis consists of protective antigen (PA), edema factor (EF), and lethal factor (LF). As a first step in developing a more efficacious anthrax vaccine, recombinant plasmids containing the PA gene have been isolated. A library was constructed in the E. coli vector pBR322 from Bam HI-generated fragments of the
Stephen H. Leppla, Michael H. Vodkin
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Immunogenic and protective antigens of Brucella as vaccine candidates
Comparative Immunology, Microbiology and Infectious Diseases, 2019Brucella is an intracellular pathogen that causes abortion in domestic animals and undulant fever in humans. Due to the lack of a human vaccine against brucellosis, animal vaccines play an important role in the management of animal and human brucellosis for decades. Strain 19, RB51 and Rev1 are the approved Brucella spp.
Reza Mirnejad +3 more
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Genetic identification of antigens protective against coccidia
Parasite Immunology, 2006SUMMARY The Eimeria species, causative agents of the disease coccidiosis, are genetically complex protozoan parasites endemic in livestock. Drug resistance remains commonplace among the Eimeria, and alternatives to chemotherapeutic control are being sought. Vaccines based upon live formulations of parasites are effective, but production costs are high,
M W Shirley +2 more
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Properties of a protective protein antigen of Erysipelothrix rhusiopathiae
Veterinary Microbiology, 1993Erysipelothrix rhusiopathiae is a widely distributed mucosal commensal of the alimentary tracts of vertebrates. Antibodies to a 66-64 kDa protein released from the cell surface have been shown to be involved in protective immunity. Mice immunized with the purified 66-64 kDa protein from strain T28, serotype 2b were protected against challenge by the ...
Martin M. Groschup, John F. Timoney
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The protective antigen of malarial sporozoites (Plasmodium berghei) is a differentiation antigen.
The Journal of Immunology, 1981Abstract Pb44, the protective antigen of rodent malaria sporozoite (Plasmodium berghei) covers the entire surface of mature, salivary gland sporozoites. This antigen is undetectable in approximately 50% of the immature, i.e., oocyst sporozoites. On the surface of the remaining oocyst sporozoites, Pb44 is found in patches. Pb44 is present
M, Aikawa +3 more
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Antigens of Taeniid Cestodes in Protection, Diagnosis and Escape
1985Parasites of the family Taeniidae (the taeniids) have a worldwide distribution but tend to have a higher prevalence in the developing countries. This is probably the most important cestode family as it contains several zoonotic species which cause health hazards to man and expense due to medical treatment.
L. J. S. Harrison, R. M. E. Parkhouse
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Virulence determinants and protective antigens of Francisella tularensis
Current Opinion in Microbiology, 2003Very little is known about virulence mechanisms of the highly virulent bacterium Francisella tularensis. Specific genetic features of F. tularensis have been obstacles for the development of effective tools for genetic manipulation. However, recent genomic sequencing and large-scale proteomic work have resulted in a substantial increase in the ...
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