Results 131 to 140 of about 17,058,241 (360)

Silent voices : supporting children and young people affected by parental alcohol misuse [PDF]

, 2012
Main table of contents: • Summary of Key Messages and Recommendations • Section One: Background • Section Two: Methodology • Section Three: Consultation with children and young people • Section Four: Review Findings • Research ...
Adamson, Jon, Templeton, Lorna
core  

Risk factors and protective factors associated with incident or increase of frailty among community-dwelling older adults: A systematic review of longitudinal studies

PLoS ONE, 2017
Introduction Frailty is one of the greatest challenges facing our aging population, as it can lead to adverse outcomes such as institutionalization, hospitalization, and mortality.
Zeyun Feng, M. Lugtenberg, C. Franse, Xinye Fang, Shanlian Hu, C. Jin, H. Raat   +6 more
semanticscholar   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Risk and Protective Factors in addiction Proneness among High School Adolescents

Salāmat-i ijtimā̒ī, 2018
Background and Objective: Some unfavorable social and family settings increase the person's vulnerability to substance abuse and predispose a person to addiction. This study aims to investigate the risk and protective factors of addiction proneness among
Ali Zeinali, Hassan-Pasha sharifi
doaj  

Family Functioning And Child Well-Being Amongst Urban Malay Single Mother Families Influence Of Risk And Protective Factors. [PDF]

, 2005
A large and growing number of Malaysian families with children are headed by single mothers. Past research has found that single mother families and their children experience more difficulties in the context of family life and well-being than two ...
K. Doshi, Anjli Panalal
core  

Lipid oxidation in meat: mechanisms and protective factors – a review

Food Science and Technology, 2018
Lipid oxidation is the main process responsible for the quality deterioration of meat and meat products by reducing shelf life (Min & Ahn, 2005). Lipid oxidation affects color, texture, nutritional value, taste, and aroma leading to rancidity, wish is ...
Ana Beatriz Amaral, M. Silva, S. Lannes
semanticscholar   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source