Results 151 to 160 of about 1,176,869 (313)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Risk and protective factors of near-lethal suicide attempts in adolescents. [PDF]

Front Psychiatry
Chen A, Franke S, Stolz A, Papsdorf R, von Polier G, Radeloff D.   +5 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Suicide attempts among youth attending special education centres: risk and protective factors. [PDF]

Postep Psychiatr Neurol
Pisarska A, Borucka A, Ostaszewski K.
europepmc   +1 more source

Resilience in chronic disease : the relationships among risk factors, protective factors, adaptive outcomes, and the level of resilience in adults with diabetes

, 2009
Background: There are innumerable diabetes studies that have investigated associations between risk factors, protective factors, and health outcomes; however, these individual predictors are part of a complex network of interacting forces.
Huang, Min-Feng
core  

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Editorial: Biopsychosocial Protective Factors Related to Antisocial Behaviors

Frontiers in Psychology, 2021
Martha Frías Armenta, Ana M. Martín, Nadia Saraí Corral-Frías   +2 more
doaj   +1 more source

Endogenous factor protects vision [PDF]

Nature Reviews Endocrinology, 2019
openaire   +2 more sources

Risk and Protective Factors of Alcohol Use Identified by Community Providers and Stakeholders in Hawai'i: Qualitative Data Analysis.

, 2018
The purpose of this study was to identify community providers' perspectives on risk and protective factors for youth alcohol use in Hawai'i to inform future trainings of providers.
Goya, Danilyn K, Garza, Codie M, An, Ji-Young, Wagner, Allison F, Nigg, Claudio R, Konishi, Minami   +5 more
core  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source