Results 71 to 80 of about 2,501,522 (306)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Department of Family and Protective Services Vision
, 2018 Newsletter of the Department of Family and Protective Services containing departmental news and announcements, deadlines, and other information of importance to Family and Protective ...
Texas. Department of Family and Protective Services.
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Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
ABOUT PROVIDING QUALITY GROUND STATE OF RAIL TRACK
Nauka ta progres transportu, 2010 The problems of providing the design quality for the substructure of railway track are considered.
I. O. Bondarenko
doaj
Texas Department of Family and Protective Services Annual Financial Report
, 2014 Annual financial report of the Texas Department of Family and Protective Services documenting income, expenditures, and other relevant financial information for fiscal year ...
Texas. Department of Family and Protective Services.
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Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Procedia Engineering, 2014 AbstractA process hazard analysis (PHA), such as a Hazard and Operability Study (HAZOP), is a useful tool in identifying potential hazard scenarios; however, a PHA can only give a qualitative indication of whether sufficient safeguards exist to mitigate the hazards. Layer of Protection Analysis (LOPA) is a risk management technique commonly used in the
openaire +1 more source
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
Multi-bed separation grouting in “three soft” thick coal seams mining and its application
Meitan kexue jishuAccurate identification of the grouting position in overburden isolated grouting and the reasonable determination of the protective layer thickness are of significant importance for preventing surface subsidence and protecting surface buildings and ...
Wenbing GUO +5 more
doaj +1 more source