Results 51 to 60 of about 242,800 (216)

Interfacial Modulation of Lithium Deposition via an Adaptive Poly(Ether‐Thiourea) Protective Layer

open access: yesCarbon Energy
Lithium metal is a promising anode material for high‐energy‐density batteries; however, its practical applications are significantly hindered by unstable lithium deposition and dendrite growth at the solid electrolyte interface.
Yongsheng Zhang   +8 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

ABOUT PROVIDING QUALITY GROUND STATE OF RAIL TRACK

open access: yesNauka ta progres transportu, 2010
The problems of providing the design quality for the substructure of railway track are considered.
I. O. Bondarenko
doaj  

Multi-bed separation grouting in “three soft” thick coal seams mining and its application

open access: yesMeitan kexue jishu
Accurate identification of the grouting position in overburden isolated grouting and the reasonable determination of the protective layer thickness are of significant importance for preventing surface subsidence and protecting surface buildings and ...
Wenbing GUO   +5 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

Protective Layer and Current Collector Design for Interface Stabilization in Lithium-Metal Batteries

open access: yesBatteries
Recent advancements in lithium-metal-based battery technology have garnered significant attention, driven by the increasing demand for high-energy storage devices such as electric vehicles (EVs).
Dayoung Kim, Cheolhwan Song, Oh B. Chae
doaj   +1 more source

A Method for Obtaining the Real Off-State Breakdown Voltage of AlGaN/GaN MIS-HEMTs in On-Wafer Tests by Optimizing Protective Layer

open access: yesIEEE Journal of the Electron Devices Society, 2019
We demonstrate a method for testing the real off-state breakdown voltage (VBD) of AlGaN/GaN metal-insulator-semiconductor high electron mobility transistor (MIS-HEMTs) in on-wafer tests.
Sheng Gao   +4 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

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