Results 51 to 60 of about 2,501,522 (306)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Surface fatigue microcracks in turbocompressor blades of a turboshaft engine

open access: yesApplied and Computational Mechanics
Rescue and military helicopters are sometimes exposed to extraordinary operating conditions. Such loading can cause non-standard fatigue defects with very specific types of failure.
Pavlas J., Růžička M., Slavík S.
doaj   +1 more source

Research on the protection range of pressure-relief in the mining of upper protective layer

open access: yesGong-kuang zidonghua, 2021
At present, the research on the protective layer pressure relief range mainly focuses on the analysis of the evolution characteristics of coal seam stress, deformation and plastic failure and the pressure relief range of the lower protective layer mining.
QIN Ruxiang1,2, YANG Ke2, CHENG Jian3
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

open access: yesFEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

Study on characteristics of coal-rock failure and fracture evolution in mining-induced space of gob-side entry retaining

open access: yesMeikuang Anquan
To address the problem of frequent gas overrun in gob-side entry retaining of protective layers in outburst-prone coal mines, taking the 3207 protective layer working face of Zhongxing Coal Industry as the engineering background, this study adopted a ...
Ke ZHOU   +5 more
doaj   +1 more source

Numerical and Similarity Simulation Study on the Protection Effect of Composite Protective Layer Mining with Gently Inclined Thick Coal Seam

open access: yesShock and Vibration, 2021
Protective layer mining, as a dominating method for preventing coal and gas outburst, is generally adopted in highly gassy coal mines. In the absence of a suitable thickness coal seam to serve as the protective layer, the rock-coal composite protective ...
Jianhong Ma, Chao Hou, Jiangtao Hou
doaj   +1 more source

Protective Measurement: A Paradigm Shift in Understanding Quantum Mechanics [PDF]

open access: yes, 2013
This article introduces the method of protective measurement and discusses its deep implications for the foundations of quantum ...
Gao, Shan
core  

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Layer-by-Layer-Coated Cellulose Fibers Enable the Production of Porous, Flame-Retardant, and Lightweight Materials

open access: yes
New sustainable materials produced by green processing routes are required in order to meet the concepts of circular economy. The replacement of insulating materials comprising flammable synthetic polymers by bio-based materials represents a potential ...
Lorenza Maddalena (5777810)   +7 more
core   +2 more sources

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