Results 71 to 80 of about 467,085 (263)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

CUSMA & Technical Protection Measures

, 2019
Presented at the 2019 ABC Copyright Conference in Saskatoon, SK.
openaire   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Integration of soil and water conservation measures in an intensively cultivated watershed – a case study of Jihlava river basin (Czech Republic)

European Countryside, 2017
Snížení vstupů dusíku a fosforu do povrchových vod z plošných zemědělských zdrojů vyžaduje cílené uplatňování diferencovaných opatření. V rámci studie zaměřené na ochranu půdy a vody v povodí Jihlavy nad vodním dílem Dalešice byly identifikovány oblasti ...
Konečná Jana, Karásek Petr, Fučík Petr, Podhrázská Jana, Pochop Michal, Ryšavý Stanislav, Hanák Roman   +6 more
doaj   +1 more source

Effects of soil cover and protective measures on reducing runoff and soil loss under artificial rainfall

Soil and Water Research, 2015
The hazards from wind, sand, and soil erosion caused by human activities, such as residue slopes in abandoned urban mines, have resulted in a vicious circle of environmental degradation.
Yan ZHANG, Mingming FENG, Jianying YANG, Tingning ZHAO, Hailong WU, Changqing SHI, Yi SHEN   +6 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Mental health of residents of radioactively contaminated territories of the Chelyabinsk region in the late period after the resettlement

Радиационная гигиена
In case of radiation accidents, one of the radical protective measures is the evacuation of residents from contaminated areas. Its purpose is to reduce the possible radiation effect to the population. At the same time, evacuation itself becomes a serious
E. Yu. Burtovaia
doaj   +1 more source

Legal entities and criminal law – principles of sanctioning

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2013
The article deals with the issue of sanctioning of legal entities in connection with corporate criminal liability introduced after 1 January 2012. It provides a characterization of the sanctioning system provided for under the Act No. 418/2011 Coll.
Věra Kalvodová
doaj   +1 more source