Results 111 to 120 of about 8,016,259 (306)

Parameter Optimization of the Corrugated Whipple Protective Structure under Hypervelocity Impact

Gaoya wuli xuebao
The geometric configuration of the corrugated Whipple protective structure significantly influences their protective capability against hypervelocity impact.
Jia’ao GUO, Qiuzu YANG, Xiaochuan LIU, Yunfei YIN, Zhiqiang LI   +4 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Kinship Quarterly, October 2018

, 2018
Quarterly newsletter related to the "Kinship Care by Child Protective Services (CPS)" program run by the Texas Department of Family and Protective Services containing departmental information and announcements, deadlines, and other information of ...
Texas. Department of Family and Protective Services.
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Kinship Quarterly, April 2015

, 2015
Quarterly newsletter related to the "Kinship Care by Child Protective Services (CPS)" program run by the Texas Department of Family and Protective Services containing departmental information and announcements, deadlines, and other information of ...
Texas. Department of Family and Protective Services.
core  

Kinship Quarterly, January 2021

, 2021
Quarterly newsletter related to the "Kinship Care by Child Protective Services (CPS)" program run by the Texas Department of Family and Protective Services containing departmental information and announcements, deadlines, and other information of ...
Texas. Department of Family and Protective Services.
core  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Study on Damage Behavior and Anti-Explosion Performance of Steel Fiber-Reinforced Cellular Concrete Under Underwater Contact Explosion

Buildings
To explore the damage mitigation mechanism of steel fiber-reinforced cellular concrete (SFR-CC) under underwater explosion loading, this study systematically analyzes two key variables: steel fiber volume fraction (0.5%, 1.0%, 1.5%, and 2.0%) and ...
Hu Huang, Shubo Dai, Kelei Cao, Changxing Tang, Xiancai Zhang, Changhui Zhang, Qingming Qiu   +6 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source