Results 61 to 70 of about 8,016,259 (306)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Designed Azolopyridinium Salts Block Protective Antigen Pores In Vitro and Protect Cells from Anthrax Toxin [PDF]

, 2013
Background:Several intracellular acting bacterial protein toxins of the AB-type, which are known to enter cells by endocytosis, are shown to produce channels.
Barth, Holger, Anika Bronnhuber, Benz, Roland, Hajós György, Markus Huber-Lang, Hajós, György, Kerstin Duscha, Riedl Zsuzsanna, Beitzinger, Christoph, Riedl, Zsuzsanna, Duscha Kerstin, György Hajós, Huber-Lang Markus, Beitzinger Christoph, Barth Holger, Duscha, Kerstin, Bronnhuber, Annika, Benz Roland, Christoph Beitzinger, Roland Benz, Holger Barth, Bronnhuber Anika, Bronnhuber, Anika, Huber-Lang, Markus, Zsuzsanna Riedl   +24 more
core   +2 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Analysis of protective performance of large ship's cylindrical underwater protection structure

Zhongguo Jianchuan Yanjiu
ObjectiveIn response to the problems of high weight and relatively low protective efficiency associated with traditional multicamerate structures (i.e., void compartment-liquid tank-void compartment), this study explores the protective performance of ...
Bowen ZHANG, Chenxi NIE, Xiang JI, Furen MING, Aman ZHANG   +4 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Certification tests of a protective device such as ROPS to ensure safe usage of tractors

MATEC Web of Conferences, 2018
According to the safety requirements, all protective devices of tractor units are subject to obligatory certification. One of the main means of protecting the operator during overturning is ROPS system.
Troyanovskaya Irina, Kalugin Anton
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Kinship Quarterly: Strengthening Families [PDF]

, 2021
Quarterly newsletter related to the "Kinship Care by Child Protective Services (CPS)" program run by the Texas Department of Family and Protective Services containing departmental information and announcements, deadlines, and other information of ...
Texas. Department of Family and Protective Services.
core   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source