Results 71 to 80 of about 552,345 (264)

Biomimetic multi-layered protective materials with prestress and a periodic laminated structure

Journal of Materiomics
The nacreous layer of shells has become an excellent biomimetic template of materials due to its unique structure. Inspired by the highly complex multilayered structure of shells, biomimetic layered composite protective materials with outstanding ...
Xin Liu, Fan Zhang, Ji Zou, Weimin Wang, Wei Ji, Zhengyi Fu   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Topological optimization of ballistic protective structures through genetic algorithms in a vulnerability-driven environment

Defence Technology
Reducing the vulnerability of a platform, i.e., the risk of being affected by hostile objects, is of paramount importance in the design process of vehicles, especially aircraft.
Salvatore Annunziata, Luca Lomazzi, Marco Giglio, Andrea Manes   +3 more
doaj   +1 more source

Cross-sectional relationship of perceived familial protective factors with depressive symptoms in vulnerable youth

BMC Psychiatry, 2018
Background There are multiple negative consequences associated with heavy episodic drinking and close associations between substance abuse and depression, alcohol-intoxicated adolescents (AIA) represent a vulnerable group.
Hanna E. Schwendemann, Heidi Kuttler, Thomas Mößle, Eva Maria Bitzer   +3 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

ANALYSIS OF THE EFFECTIVENESS OF TACTICAL PROTECTION SCHEMES OF STUDENT HANDBALL TEAMS

Физическая культура. Спорт. Туризм. Двигательная рекреация, 2020
. This article discusses approaches to the problem of building team defense tactics. The statistical data of the results of the games of the student handball team were analyzed and structured, as a result of which the effectiveness of tactical defense ...
Aleksandr Vladimirovich Radchenko , Vadim Anatolevich Harkovskiy   +1 more
doaj  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source