Results 121 to 130 of about 9,193,993 (329)

Disulfide bridge-dependent dimerization triggers FGF2 membrane translocation into the extracellular space

eLife
Fibroblast growth factor 2 (FGF2) exits cells by direct translocation across the plasma membrane, a type I pathway of unconventional protein secretion. This process is initiated by phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2)-dependent formation of ...
Fabio Lolicato, Julia P Steringer, Roberto Saleppico, Daniel Beyer, Jaime Fernandez-Sobaberas, Sebastian Unger, Steffen Klein, Petra Riegerová, Sabine Wegehingel, Hans-Michael Müller, Xiao J Schmitt, Shreyas Kaptan, Christian Freund, Martin Hof, Radek Šachl, Petr Chlanda, Ilpo Vattulainen, Walter Nickel   +17 more
doaj   +1 more source

Comprehensive characterization of protein–protein interactions perturbed by disease mutations

, 2021
Feixiong Cheng, Junfei Zhao, Yang Wang, Weiqiang Lü, Zehui Liu, Yadi Zhou, William R. Martin, Rui‐Sheng Wang, Jin Huang, Tong Hao, Hong Yue, Jing Ma, Yuan Hou, Jessica A. Castrillon, Jiansong Fang, Justin D. Lathia, Ruth A. Keri, Felice C. Lightstone, Elliott M. Antman, Raúl Rabadán, David E. Hill, Charis Eng, Marc Vidal, Joseph Loscalzo   +23 more
openalex   +2 more sources

Knowledge-based energy functions for computational studies of proteins

, 2006
This chapter discusses theoretical framework and methods for developing knowledge-based potential functions essential for protein structure prediction, protein-protein interaction, and protein sequence design.
A. Ben-Naim, A. Godzik, A. Godzik, A. Rossi, A.J. Bordner, A.V. Finkelstein, B. Fain, B. Krishnamoorthy, B. Kuhlman, B. Schölkopf, B.H. Park, B.I. Dahiyat, B.J. McConkey, B.O. Mitchell, C. Anfinsen, C. Carter Jr., C. Czaplewski, C. Hoppe, C. Hu, C. Micheletti, C. Papadimitriou, C. Zhang, C. Zhang, C. Zhang, C. Zhang, C. Zhang, C.A. Rohl, C.B. Anfinsen, C.M.R Lemer, C.S. Mészáros, D. Gilis, D. Gilis, D. Gilis, D. Tobi, D. Xu, E. Venclovas, E.I. Shakhnovich, E.I. Shakhnovich, F.A. Momany, H. Dobbs, H. Edelsbrunner, H. Gan, H. Li, H. Li, H. Lu, H. Zhou, H.S. Chan, I. Muegge, J. Khatun, J. Liang, J.A. Kocher, J.A. Rank, J.M. Deutsch, J.R. Bienkowska, K. Nishikawa, K. Sale, K.H. Lee, K.K. Koretke, K.K. Koretke, K.T. Simons, L. Adamian, L. Adamian, L. Adamian, L.A. Mirny, L.L. Looger, L.M. Amzel, M. Karplus, M. Levitt, M. Vendruscolo, M. Vendruscolo, M.H. Hao, M.H. Hao, M.J. Sippl, M.J. Sippl, M.J. Sippl, M.P. Eastwood, M.R. Betancourt, M.S. Friedrichs, N. Karmarkar, N.V. Buchete, N.V. Buchete, P. Koehl, P. Koehl, P.D. Thomas, P.D. Thomas, P.G. Wolynes, P.J. Munson, R. Goldstein, R. Guerois, R. Jackups Jr., R. Janicke, R. Méndez, R. Samudrala, R. Samudrala, R.B. Hill, R.I. Dima, R.J. Vanderbei, R.K. Singh, R.L. Jernigan, R.S. DeWitte, S. Liu, S. Miyazawa, S. Miyazawa, S. Miyazawa, S. Shimizu, S. Shimizu, S. Tanaka, S.J. Wodak, T. Kortemme, T. Kortemme, T. Kortemme, T. Lazaridis, T.L. Chiu, U. Bastolla, U. Bastolla, V. Vapnik, V. Vapnik, V.N. Maiorov, W.P. Russ, X. Li, X. Li, Y. Duan, Y. Park, Y. Xia   +123 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

A protein-protein interaction dictates Borrelial infectivity

Scientific Reports, 2017
Two Borrelia burgdorferi interacting proteins, BB0238 and BB0323, play distinct roles in pathogen biology and infectivity although a significance of their interaction remained enigmatic.
Meghna Thakur, Kavita Sharma, Kinlin Chao, Alexis A. Smith, Osnat Herzberg, Utpal Pal   +5 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Complex structure of cytochrome c–cytochrome c oxidase reveals a novel protein–protein interaction mode

EMBO Journal, 2016
Mitochondrial cytochrome c oxidase (CcO) transfers electrons from cytochrome c (Cyt.c) to O2 to generate H2O, a process coupled to proton pumping. To elucidate the mechanism of electron transfer, we determined the structure of the mammalian Cyt.c–CcO ...
S. Shimada, K. Shinzawa-Itoh, J. Baba, Shimpei Aoe, A. Shimada, E. Yamashita, Jiyoung Kang, M. Tateno, S. Yoshikawa, T. Tsukihara   +9 more
semanticscholar   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

A Unified Model of Mammalian BCL-2 Protein Family Interactions at the Mitochondria [PDF]

, 2011
Fabien Llambi, Tudor Moldoveanu, Stephen W. G. Tait, Lisa Bouchier‐Hayes, Jamshid Temirov, Laura L. McCormick, Christopher P. Dillon, Douglas R. Green   +7 more
openalex   +1 more source