Results 141 to 150 of about 9,193,993 (329)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

HMNPPID—human malignant neoplasm protein–protein interaction database

Human Genomics, 2019
Background Protein–protein interaction (PPI) information extraction from biomedical literature helps unveil the molecular mechanisms of biological processes.
Qingqing Li, Zhihao Yang, Zhehuan Zhao, Ling Luo, Zhiheng Li, Lei Wang, Yin Zhang, Hongfei Lin, Jian Wang, Yijia Zhang   +9 more
doaj   +1 more source

ICBS: a database of interactions between protein chains mediated by β-sheet formation [PDF]

, 2004
Yimeng Dou, Pierre-François Baisnée, Gianluca Pollastri, Yann Pécout, James S. Nowick, Pierre Baldi   +5 more
openalex   +1 more source

Revisiting the Function of p21CDKN1A in DNA Repair: The Influence of Protein Interactions and Stability [PDF]

, 2022
Giulio Ticli, Ornella Cazzalini, Lucia Anna Stivala, Ennio Prosperi   +3 more
openalex   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Research Progress in Porcine Reproductive and Respiratory Syndrome Virus–Host Protein Interactions [PDF]

, 2022
Hang Zhang, Huiyang Sha, Limei Qin, Na Wang, Weili Kong, Liangzong Huang, Mengmeng Zhao   +6 more
openalex   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Characterization of Protein Complexes and Subcomplexes in Protein-Protein Interaction Databases

Biochemistry Research International, 2015
The identification and characterization of protein complexes implicated in protein-protein interaction data are crucial to the understanding of the molecular events under normal and abnormal physiological conditions.
Nazar Zaki, Elfadil A. Mohamed, Antonio Mora   +2 more
doaj   +1 more source

A SARS-CoV-2 surrogate virus neutralization test based on antibody-mediated blockage of ACE2–spike protein–protein interaction

Nature Biotechnology, 2020
C. Tan, W. Chia, X. Qin, Pei Liu, M. Chen, Charles Tiu, Zhiliang Hu, V. Chen, B. Young, W. Sia, Yee-Joo Tan, Randy Foo, Yongxiang Yi, D. Lye, D. Anderson, Lin‐Fa Wang   +15 more
semanticscholar   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source