Results 171 to 180 of about 2,229,925 (272)

Corrigendum: HPLC for at-line reaction monitoring and purification improves yield and purity of tRNA

Frontiers in Molecular Biosciences
Polona Megušar, Ewen D. D. Calder, Ewen D. D. Calder, Tina Vodopivec Seravalli, Sergeja Lebar, Louise J. Walport, Louise J. Walport, Rok Sekirnik   +7 more
doaj   +1 more source

Optimized Quantitative Bacterial Two-Hybrid (qB2H) for Protein-Protein Interaction Assessment. [PDF]

Comput Struct Biotechnol J
Guyot A, Maillard E, Ferreira-Pinto K, Plançon-Arnould L, Nadaradjane AA, Guérois R, Ochsenbein F, Martin L, Ramos OHP.   +8 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Protein-Protein Interaction Prediction with Identification of Putative Interaction Patterns

, 2007
蛋白質交互用作與其作用位置是了解生物體內運作的重要資訊，現在雖然已發展了許多實驗的方法來加以探測，但能得到的結果仍只是自然界的極小部分，為了增加探索速度，不少研究人員開發計算性的方法來預測，交互作用預測的準確度大致上都可以接受，但不是每個方法都能辨識出交互作用發生的位置，而一般用來預測作用介面的方法大都需要有三級結構的資訊來輔助，可是相較於已經解出的基因體序列，已知的結構資訊實在是太少了，所以這類的方法並不見得適用。 我們提出一個資料探勘演算法，其修改自挖掘關聯規則的Apriori演算法 ...
Tsai, Meng-Jia, 蔡孟家
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

A Review and Experimental Analysis of Supervised Learning Systems and Methods for Protein-Protein Interaction Detection. [PDF]

Int J Mol Sci
Taha K.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The protein-protein interaction network analysis in idiopathic posterior uveitis. [PDF]

Indian J Ophthalmol
Shariati MM, Moravvej Z.
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

A paired sequence language model for protein-protein interaction modeling. [PDF]

Nat Commun
Liu J, Chen H, Zhang Y.
europepmc   +1 more source