Results 271 to 280 of about 9,193,993 (329)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Identification of regulatory sequences in Aca11 and Aca13 for detection of anti-CRISPR and protein-protein interaction. [PDF]

Nucleic Acids Res
Song G, Li J, Han J, Gao X, Tian C, Zhang F, Tian Y.   +6 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Integrating Protein-protein Interaction Networks and Machine Learning to Identify Biomarkers of Cancer Onset

Chen H, Ma M, Liu H, Yang Q, Wang J, Zheng J.   +5 more
europepmc   +1 more source

MPIDNN-GPPI: multi-protein language model with an improved deep neural network for generalized protein‒protein interaction prediction. [PDF]

BMC Genomics
Li Y, Wang C, Gu H, Long Z, Fan M, Li L.
europepmc   +1 more source

Human HMGB1 directly facilitates interactions between nucleotide excision repair proteins on triplex-directed psoralen interstrand crosslinks

, 2009
Sabine S. Lange, Madhava C. Reddy, Karen M. Vásquez   +2 more
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Shared Genetic Architecture Among Severe Mental Disorders: A System Biology Approach Based on Protein-Protein Interaction. [PDF]

Brain Behav
Guillen-Burgos HF, Vanegas V, Gonzalez I, Caicedo AM, Arango V, Galvez-Florez JF, Anaya JM, McIntyre RS, Terán W.   +8 more
europepmc   +1 more source

Characterization and Intracellular Localization of the Epstein-Barr Virus Protein BFLF2: Interactions with BFRF1 and with the Nuclear Lamina

, 2005
Roberta Gonnella, Antonella Farina, Roberta Santarelli, Salvatore Raffa, Regina Feederle, Roberto Bei, Marisa Granato, Andrea Modesti, Luigi Frati, Henri‐Jacques Delecluse, Maria Rosaria Torrisi, Antonio Angeloni, Alberto Faggioni   +12 more
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source