Results 301 to 310 of about 9,193,993 (329)

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

The protein-protein interaction between two spliced leader <i>trans</i> -splicing factors is mediated by two interlinked α-helical domains. [PDF]

MicroPubl Biol
Eijlers P, Pettitt J, Müller B.
europepmc   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Sensitivity analysis on protein-protein interaction networks through deep graph networks. [PDF]

BMC Bioinformatics
Dipalma A, Fontanesi M, Micheli A, Milazzo P, Podda M.   +4 more
europepmc   +1 more source

Protein-Protein Interaction Gene Sets and KEGG Pathway Results Post-STRING Clustering.

Weidong Liu (444731), Jiaying Gao (12436513), Shuqiang Ren (9236870), Buhe Nashun (9330545), Fei Gao (29262)   +4 more
openalex   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Inhibition of the Clathrin Terminal Domain-Amphiphysin Protein-Protein Interaction. Probing the Pitstop 2 Aromatic Moiety. [PDF]

ChemMedChem
Prichard K, Robertson MJ, Chau N, Xue J, Neuenschwander M, Fink U, Horatscheck A, Nazare M, Robinson PJ, Haucke V, McCluskey A.   +10 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

DiCE: differential centrality-ensemble analysis based on gene expression profiles and protein-protein interaction network. [PDF]

Nucleic Acids Res
Pashaei E, Liu S, Li K, Zang Y, Yang L, Lautenschlaeger T, Huang J, Lu X, Wan J.   +8 more
europepmc   +1 more source