Results 1 to 10 of about 6,951 (92)

Discovery of a new class of inhibitors for the protein arginine deiminase type 4 (PAD4) by structure-based virtual screening [PDF]

BMC Bioinformatics, 2012
Background Rheumatoid arthritis (RA) is an autoimmune disease with unknown etiology. Anticitrullinated protein autoantibody has been documented as a highly specific autoantibody associated with RA.
Teo Chian, Shave Steven, Thean Chor Adam, Salleh Abu, Abdul Rahman Mohd Basyaruddin, Walkinshaw Malcolm D, Tejo Bimo A   +6 more
doaj   +6 more sources

Discovery of new inhibitor for the protein arginine deiminase type 4 (PAD4) by rational design of α-enolase-derived peptides [PDF]

Computational Biology and Chemistry, 2021
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease affecting about 0.24 % of the world population. Protein arginine deiminase type 4 (PAD4) is believed to be responsible for the occurrence of RA by catalyzing citrullination of proteins. The citrullinated proteins act as autoantigens by stimulating an immune response.
Abu Bakar Salleh, Mohd Basyaruddin Abdul Rahman, Bimo A Tejo   +2 more
exaly   +3 more sources

Inhibition of protein arginine deiminase 4 prevents inflammation-mediated heart failure in arthritis

Life Science Alliance, 2023
Inhibition of protein arginine deiminase 4 (PAD4), with an orally available inhibitor (JBI-589), prevents the development of hypertrophic cardiomyopathy and diastolic heart failure in murine inflammatory arthritis with reduced neutrophil infiltration ...
Lukas A Heger, Nicolas Schommer, Shoichi Fukui, Stijn Van Bruggen, Casey E Sheehy, Long Chu, Sridharan Rajagopal, Dhanalakshmi Sivanandhan, Bruce Ewenstein, Denisa D Wagner   +9 more
doaj   +1 more source

Neutrophil Extracellular Traps Tied to Rheumatoid Arthritis: Points to Ponder

Frontiers in Immunology, 2021
In recent years, neutrophil extracellular traps at the forefront of neutrophil biology have proven to help capture and kill pathogens involved in the inflammatory process. There is growing evidence that persistent neutrophil extracellular traps drive the
Wenpeng Song, Jing Ye, Nanfang Pan, Chunyu Tan, Martin Herrmann   +4 more
doaj   +1 more source

Tocilizumab decreases T cells but not macrophages in the synovium of patients with rheumatoid arthritis while it increases the levels of serum interleukin-6 and RANKL

RMD Open, 2021
Objectives Our knowledge about the effect of tocilizumab (TCZ) on the synovium in rheumatoid arthritis (RA) is limited. The aim of this study was to investigate the effect of TCZ on citrullination and on inflammation in the synovial tissue and in the ...
Katerina Chatzidionysiou, Bence Rethi, Vijay Joshua, Alexandra Circiumaru, Marianne Engstrom, Anca Catrina, Erik af Klint, Aase Hensvold   +7 more
doaj   +1 more source

Identification of a Novel Serological Marker in Seronegative Rheumatoid Arthritis Using the Peptide Library Approach

Frontiers in Immunology, 2021
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation mainly affecting the joints leading to cartilage and bone destruction.
Caterina Bason, Alessandro Barbieri, Nicola Martinelli, Bianca Olivieri, Giuseppe Argentino, Elena Bartoloni, Ruggero Beri, Gnaneshwer Jadav, Antonio Puccetti, Elisa Tinazzi, Claudio Lunardi   +10 more
doaj   +1 more source

Functional role of dimerization of human peptidylarginine deiminase 4 (PAD4). [PDF]

PLoS ONE, 2011
Peptidylarginine deiminase 4 (PAD4) is a homodimeric enzyme that catalyzes Ca²⁺-dependent protein citrullination, which results in the conversion of arginine to citrulline.
Yi-Liang Liu, Yu-Hsiu Chiang, Guang-Yaw Liu, Hui-Chih Hung   +3 more
doaj   +1 more source

Elevated Biomarkers of NETosis in the Serum of Pediatric Patients With Type 1 Diabetes and Their First-Degree Relatives

Frontiers in Immunology, 2021
Type 1 diabetes (T1D) is an autoimmune disorder with unambiguous involvement of both innate and adaptive immune mechanisms in the destruction of pancreatic beta cells. Recent evidence demonstrated that neutrophils infiltrate the pancreas prior to disease
Adam Klocperk, Jana Vcelakova, Petra Vrabcova, Irena Zentsova, Lenka Petruzelkova, Zdenek Sumnik, Stepanka Pruhova, Anna Sediva, Zuzana Parackova   +8 more
doaj   +1 more source

The multiple roles of hypothetical gene BPSS1356 in Burkholderia pseudomallei. [PDF]

PLoS ONE, 2014
Burkholderia pseudomallei is an opportunistic pathogen and the causative agent of melioidosis. It is able to adapt to harsh environments and can live intracellularly in its infected hosts.
Hokchai Yam, Ainihayati Abdul Rahim, Suriani Mohamad, Nor Muhammad Mahadi, Uyub Abdul Manaf, Alexander Chong Shu-Chien, Nazalan Najimudin   +6 more
doaj   +1 more source

Gimap5 Inhibits Lung Cancer Growth by Interacting With M6PR

Frontiers in Oncology, 2021
ObjectiveSeveral studies have demonstrated the impacts of GTPases of immunity-associated proteins (GIMAPs) on malignant cells. However, the mechanisms through which Gimap5 regulates lung cancer cells are yet to be thoroughly investigated in the ...
Pei Dai, Zhongxiang Tang, Pinglang Ruan, Ousman Bajinka, Ousman Bajinka, Dan Liu, Yurong Tan, Yurong Tan   +7 more
doaj   +1 more source