Results 121 to 130 of about 328,904 (334)

Expression of Concern for Meconi et al., "Activation of Protein Tyrosine Kinases by Coxiella burnetii: Role in Actin Cytoskeleton Reorganization and Bacterial Phagocytosis". [PDF]

Infect Immun, 2023
American Society for Microbiology.
europepmc   +1 more source

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

Molecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian   +10 more
wiley   +1 more source

Comparative analysis of protein kinases and associated domains between Ascomycota and Basidiomycota

Journal of Integrative Agriculture, 2019
Protein kinases play an important role in every aspect of cellular life. In this study, we systemically identified protein kinases from the predicted proteomes of 59 representative fungi from Ascomycota and Basidiomycota.
Guo-liang PEI, Jun GUO, Qin-hu WANG, Zhen-sheng KANG   +3 more
doaj   +1 more source

Bioinformatic analysis of gene expression data reveals Src family protein tyrosine kinases as key players in androgenetic alopecia. [PDF]

Front Med (Lausanne), 2023
Premanand A, Reena Rajkumari B.
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Properties of FDA-approved small molecule protein kinase inhibitors: A 2024 update

Pharmacological Research
Owing to the dysregulation of protein kinase activity in many diseases including cancer, this enzyme family has become one of the most important drug targets in the 21st century.
Robert Roskoski, Jr.
doaj   +1 more source

Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck). [PDF]

, 1988
Jamey D. Marth, Jonathan A. Cooper, C S King, Steven F. Ziegler, Donald A. Tinker, Robert W. Overell, E G Krebs, Roger M. Perlmutter   +7 more
openalex   +1 more source

Pharmacological inhibition of protein tyrosine kinases axl and fyn reduces TNF-α-induced endothelial inflammatory activation in vitro. [PDF]

Front Pharmacol, 2022
Ellermann SF, Jongman RM, Luxen M, Kuiper T, Plantinga J, Moser J, Scheeren TWL, Theilmeier G, Molema G, Van Meurs M.   +9 more
europepmc   +1 more source

Preparation and characterization of renal cell peptides from fetal rats for their antitumor activity

FEBS Open Bio, EarlyView.
This study aimed to prepare renal cells (RCs) from fetal rats which were digested by enzymes. Candidate peptides RCPs were characterized by capillary HPLC and MS and their bioactivity was predicted using peptideranker. The predicted top 10 bioactive peptides were synthesized.
Zhe Zhang, Yuan Cao, Jing Du, Ying Zhang, Junxia Wang, Ying Yuan, Lianqing Sun   +6 more
wiley   +1 more source

Specific dephosphorylation of phosphoproteins by protein-serine and -tyrosine kinases. [PDF]

, 1988
Hemanta K. Kole, M Abdel-Ghany, E. Racker   +2 more
openalex   +1 more source