Results 121 to 130 of about 184,784 (335)

Src-family Protein Tyrosine Kinases: A promising target for treating Cardiovascular Diseases. [PDF]

Int J Med Sci, 2021
Zhai Y, Yang J, Zhang J, Yang J, Li Q, Zheng T.   +5 more
europepmc   +1 more source

The membrane glycoprotein encoded by the retroviral oncogene v-erb-B is structurally related to tyrosine-specific protein kinases. [PDF]

, 1984
Martin L. Privalsky, Robert Ralston, J. Michael Bishop   +2 more
openalex   +1 more source

Sustained Release of Proteins Using Region‐Specific Tunable Degradability in Hydrogels through 3D Photopatterning and Complimentary Labile Bond Chemistry

Advanced Functional Materials, EarlyView.
A series of ultraviolet‐ and near‐infrared radiation sensitive photoactivatable hydrogels are developed that can be controlled spatiotemporally down to µm precisions using one‐ and two‐photon uncaging. The latent hydroxylamine‐, hydrazine‐, and amine uncaged moieties are used to photopattern a series of diverse proteins displaying complimentary ...
Tove Kivijärvi, Carmine P. Cerrato, Taha Behroozi Kohlan, Paul O’Callaghan, Johan Kreuger, Marie Arsenian‐Henriksson, Anna Finne‐Wistrand   +6 more
wiley   +1 more source

Patients with treated indolent lymphomas immunized with BNT162b2 have reduced anti‐spike neutralizing IgG to SARS‐CoV‐2 variants, but preserved antigen‐specific T cell responses

American Journal of Hematology, Volume 98, Issue 1, Page 131-139, January 2023., 2023
Abstract Patients with indolent lymphoma undertaking recurrent or continuous B cell suppression are at risk of severe COVID‐19. Patients and healthy controls (HC; N = 13) received two doses of BNT162b2: follicular lymphoma (FL; N = 35) who were treatment naïve (TN; N = 11) or received immunochemotherapy (ICT; N = 23) and Waldenström's macroglobulinemia
Brendan Beaton, Sarah C. Sasson, Katherine Rankin, Juliette Raedemaeker, Alexander Wong, Priyanka Hastak, Chansavath Phetsouphanh, Andrew Warden, Vera Klemm, C. Mee Ling Munier, Alexandra Carey Hoppe, Fiona Tea, Aleha Pillay, Alberto Ospina Stella, Anupriya Aggarwal, Orly Lavee, Ian D. Caterson, Stuart Turville, Anthony D. Kelleher, Fabienne Brilot, Judith Trotman   +20 more
wiley   +1 more source

Kinetic parameters of the protein tyrosine kinase activity of EGF-receptor mutants with individually altered autophosphorylation sites. [PDF]

, 1988
Annemarie Honegger, Thomas J. Dull, Daniele Szapary, Akira Komoriya, Richard Kris, A Ullrich, Joseph Schlessinger   +6 more
openalex   +1 more source

Biomimetic Co‐delivery of Lenvatinib and FePt Nanoparticles for Enhanced Ferroptosis/Apoptosis Treatment of Hepatocellular Carcinoma

Advanced Healthcare Materials, EarlyView.
This study introduces a novel HCC treatment using poly lactic‐co‐glycolic acid (PLGA) nanoparticles encased in HCC cell membranes to co‐deliver Lenvatinib and FePt nanoparticles. This approach improves treatment efficacy by enhancing ferroptosis and apoptosis.
Feichao Xuan, Xingyang Zhao, Weiran Pang, Zirong Li, Xiangyi Yin, Weizhong Xie, Xiaojun Zeng, Liming Nie, Junying Yang, Shiying Li, Puxiang Lai, Chihua Fang   +11 more
wiley   +1 more source

Bruton tyrosine kinase inhibitors in the management of Waldenström macroglobulinemia

American Journal of Hematology, Volume 98, Issue 2, Page 338-347, February 2023., 2023
Abstract Bruton tyrosine kinase (BTK) inhibitors have taken a central role in the management of patients with Waldenström macroglobulinemia and are the only agents approved by the Food and Drug Administration (FDA) to treat these patients. Although associated with high rates of durable responses, unmet needs with BTK inhibitor therapy include ...
Jorge J. Castillo, Christian Buske, Judith Trotman, Shayna Sarosiek, Steven P. Treon   +4 more
wiley   +1 more source

Prediction of Small Molecule Kinase Inhibitors for Chemotherapy Using Deep Learning [PDF]

arXiv, 2019
The current state of cancer therapeutics has been moving away from one-size-fits-all cytotoxic chemotherapy, and towards a more individualized and specific approach involving the targeting of each tumor's genetic vulnerabilities. Different tumors, even of the same type, may be more reliant on certain cellular pathways more than others.
arxiv  

Characterization of four tyrosine protein kinases from the particulate fraction of rat spleen [PDF]

, 1988
Anna Maria Brunati, Lorenzo A. Pinna
openalex   +1 more source

Short‐Chain Fatty Acids Modulate Anti‐ROR1 CAR T‐Cell Function and Exhaustion in an Intestinal Adenocarcinoma‐on‐Chip Model

Advanced Healthcare Materials, EarlyView.
Short‐chain fatty acids modulate anti‐ROR1 chimeric antigen receptor (CAR) T‐cell function in an intestinal adenocarcinoma‐on‐chip model. Butyrate and propionate reduce cytotoxicity, cytokine release, and infiltration by inducing a regulatory T‐cell phenotype and T‐cell exhaustion via histone deacetylase inhibition.
Valentin D. Wegner, Adrian Feile, Miriam Alb, Michael Hudecek, Philip Hewitt, Alexander S. Mosig   +5 more
wiley   +1 more source