Protein Tyrosine Kinases: Their Roles and Their Targeting in Leukemia. [PDF]
Cancers (Basel), 2021 K Bhanumathy K +5 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
Properties of FDA-approved small molecule protein kinase inhibitors: A 2024 update
Pharmacological ResearchOwing to the dysregulation of protein kinase activity in many diseases including cancer, this enzyme family has become one of the most important drug targets in the 21st century.
Robert Roskoski, Jr.
doaj +1 more source
Comparative analysis of protein kinases and associated domains between Ascomycota and Basidiomycota
Journal of Integrative Agriculture, 2019 Protein kinases play an important role in every aspect of cellular life. In this study, we systemically identified protein kinases from the predicted proteomes of 59 representative fungi from Ascomycota and Basidiomycota.
Guo-liang PEI +3 more
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FEBS Open Bio, EarlyView.The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source
Single-cell transcriptomic profiling unravels the adenoma-initiation role of protein tyrosine kinases during colorectal tumorigenesis. [PDF]
Signal Transduct Target Ther, 2022 Zheng X +19 more
europepmc +1 more source
Protein tyrosine kinase 6 (PTK6; BRK); epidermal growth factor receptor (EGFR; ERBB1; HER1); v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 (ERBB2; HER2; Neu) [PDF]
, 2008 openalex +1 more source
Supplementary Figure 5A and 5B from Therapeutic Implications of a Human Neutralizing Antibody to the Macrophage-Stimulating Protein Receptor Tyrosine Kinase (RON), a c-MET Family Member [PDF]
, 2023 Jennifer M. O'Toole +18 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela +13 more
wiley +1 more source
Src-family Protein Tyrosine Kinases: A promising target for treating Cardiovascular Diseases. [PDF]
Int J Med Sci, 2021 Zhai Y +5 more
europepmc +1 more source