Results 101 to 110 of about 3,692,701 (303)

Tyrosine phosphorylation of myosin heavy chain during skeletal muscle differentiation: an integrated bioinformatics approach [PDF]

, 2005
Background: Previously it has been shown that insulin-mediated tyrosine phosphorylation of myosin heavy chain is concomitant with enhanced association of C-terminal SRC kinase during skeletal muscle differentiation. We sought to identify putative site(s)
RJ Edwards, Harney, D.F., Richard J. Edwards (7949342), DF Harney, Ryan K. Butler (7949339), Donal F. Harney (7949336), Butler, R., Edwards, Richard J., RK Butler   +8 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Advancements in research on the cardiovascular toxicity caused by TEC family kinases inhibitors

Frontiers in Pharmacology
The tyrosine kinase expressed in hepatocellular carcinoma (TEC) family kinases (TFKs) are a subfamily of non-receptor protein tyrosine kinases (PTKs) that include five members: TEC, bruton’s tyrosine kinase (BTK), interleukin 2-inducible T-cell kinase ...
Yi Zhang, Huangxi Fu, Xingchen Kang, Zixuan Qiu, Hao Yan, Qiaojun He, Qiaojun He, Qiaojun He, Bo Yang, Bo Yang, Bo Yang, Zhifei Xu, Peihua Luo, Peihua Luo   +13 more
doaj   +1 more source

PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis

Nature Communications, 2017
Although protein tyrosine kinases are being explored as antifibrotic agents for the treatment of systemic sclerosis, little is known about the function of counteractive protein tyrosine phosphatases in this context.
Cristiano Sacchetti, Yunpeng Bai, Stephanie M. Stanford, Paola Di Benedetto, Paola Cipriani, Eugenio Santelli, Sonsoles Piera-Velazquez, Vladimir Chernitskiy, William B. Kiosses, Arnold Ceponis, Klaus H. Kaestner, Francesco Boin, Sergio A. Jimenez, Roberto Giacomelli, Zhong-Yin Zhang, Nunzio Bottini   +15 more
doaj   +1 more source

Src mediates cytokine-stimulated gene expression in airway myocytes through ERK MAPK

Cell Communication and Signaling, 2011
The p38 and extracellular signal-regulated kinases (ERK) mitogen-activated protein kinases (MAPK) participate in cytokine-stimulated inflammatory gene expression in airway smooth muscle cells.
Halayko Andrew J, Unruh Helmut, Lontay Beata, Singer Cherie A, Gerthoffer William T   +4 more
doaj   +1 more source

Structure and molecular interaction analysis of monoclonal antibodies in complex with receptor tyrosine kinases [PDF]

, 2010
Misregulated receptor tyrosine kinases (RTKs), i.e. the epidermal growth factor receptor EGFR or the insulin-like growth factor receptor 1 (IGF-1R), can be involved in the development of cancer.
Schmiedel, Judith
core  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Control of DNA replication by NCOA4 protein in HeLa cells [PDF]

, 2009
This dissertation is focused on the functional characterization of NCOA4 protein, and in particular on its role in controlling DNA replication in HeLa cells.
Provitera, Livia
core   +1 more source

Expression of Concern for Meconi et al., "Activation of Protein Tyrosine Kinases by Coxiella burnetii: Role in Actin Cytoskeleton Reorganization and Bacterial Phagocytosis". [PDF]

Infect Immun, 2023
American Society for Microbiology.
europepmc   +1 more source

T cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase [PDF]

, 2001
After stimulation of the T cell receptor (TCR), the tyrosine residues 292 and 315 in interdomain B of the protein tyrosine kinase ZAP-70 become phosphorylated and plausibly function as docking sites for Cbl and Vav1, respectively. The two latter proteins
Magnan, A, Anne Gillet, Arrieumerlou, C, Antoine Magnan, Boyer, C, Malissen, Bernard, Vincenzo Di Bartolo, Mireille Richelme, Marie Malissen, Lin, YL, Gillet, A., Roure, A, Mura, A. M., Boyer, C., Malissen, B, Arrieumerlou, C., Malissen, M., Malissen, M, Roure, A., Richelme, M, Acuto, O, Lin, Y. L., Bernard Malissen, Claude Boyer, Malissen, B., Di Bartolo, V, Cécile Arrieumerlou, Yea-Lih Lin, Agnès Roure, Oreste Acuto, Mura, AM, Acuto, O., Richelme, M., Acuto, Oreste, Di Bartolo, V., Anne-Marie Mura, Gillet, A, Boyer, Claudine, Magnan, A.   +38 more
core   +1 more source