Journal of Cell Biology, 1992 Cells in culture reveal high levels of protein tyrosine phosphorylation in their focal adhesions, the regions where cells adhere to the underlying substratum.
Keith Burridge +2 more
exaly +2 more sources
Large‐Scale Phosphorylation Mapping Reveals the Extent of Tyrosine Phosphorylation in Arabidopsis
Molecular Systems Biology, 2008 Protein phosphorylation regulates a wide range of cellular processes. Here, we report the proteome‐wide mapping of in vivo phosphorylation sites in Arabidopsis by using complementary phosphopeptide enrichment techniques coupled with high‐accuracy mass ...
Naoyuki Sugiyama +2 more
exaly +2 more sources
Src-dependent tyrosine-phosphorylation of NM2A has a protective role against bacterial pore-forming toxins. [PDF]
PLoS PathogensPore-forming toxins (PFTs) are key bacterial virulence factors that disrupt host plasma membrane (PM) integrity, triggering cellular stress and initiating repair mechanisms.
Cláudia Brito +10 more
doaj +2 more sources
Anti-microbial cetylpyridinium chloride suppresses mast cell function by targeting tyrosine phosphorylation of Syk kinase [PDF]
Journal of ImmunotoxicologyCetylpyridinium chloride (CPC) is a quaternary ammonium antimicrobial used in numerous personal care products, human food, cosmetic products, and cleaning solutions. Yet, there is minimal published data on CPC effects on eukaryotes, immune signaling, and
Bright Obeng +16 more
doaj +2 more sources
Bio-Protocol, 2022 Cells sense and respond to mitogens by activating a cascade of signaling events, primarily mediated by tyrosine phosphorylation (pY). Because of its key roles in cellular homeostasis, deregulation of this signaling is often linked to oncogenesis.
Vidyasiri Vemulapalli +3 more
doaj +1 more source
Interaction between O-GlcNAc modification and tyrosine phosphorylation of prohibitin: implication for a novel binary switch. [PDF]
PLoS ONE, 2009 Prohibitin (PHB or PHB1) is an evolutionarily conserved, multifunctional protein which is present in various cellular compartments including the plasma membrane. However, mechanisms involved in various functions of PHB are not fully explored yet. Here we
Sudharsana R Ande +2 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Tyrosine kinases are crucial signaling components of diverse biological processes and are major therapeutic targets in various malignancies and immune-mediated disorders.
Krisztina Futosi +7 more
doaj +1 more source
Receptor tyrosine kinase (RTK) mediated tyrosine phosphor-proteome from Drosophila S2 (ErbB1) cells reveals novel signaling networks. [PDF]
PLoS ONE, 2008 Protein phosphorylation mediates many critical cellular responses and is essential for many biological functions during development. About one-third of cellular proteins are phosphorylated, representing the phosphor-proteome, and phosphorylation can ...
Srinivasan Krishnamoorthy
doaj +1 more source
Phosphorylation of AATYK1 by Cdk5 suppresses its tyrosine phosphorylation. [PDF]
PLoS ONE, 2010 Apoptosis-associated tyrosine kinase 1 (AATYK1), a novel serine/threonine kinase that is highly expressed in the brain, is involved in neurite extension and apoptosis of cerebellar granule neurons; however, its precise function remains unknown.
Koji Tsutsumi +6 more
doaj +1 more source
Tyrosine Phosphorylation of SGEF Regulates RhoG Activity and Cell Migration. [PDF]
PLoS ONE, 2016 SGEF and Ephexin4 are members of the Ephexin subfamily of RhoGEFs that specifically activate the small GTPase RhoG. It is reported that Ephexin1 and Ephexin5, two well-characterized Ephexin subfamily RhoGEFs, are tyrosine-phosphorylated by Src, and that ...
Yusuke Okuyama +3 more
doaj +1 more source