Phosphorylation of AATYK1 by Cdk5 suppresses its tyrosine phosphorylation. [PDF]
PLoS ONE, 2010 Apoptosis-associated tyrosine kinase 1 (AATYK1), a novel serine/threonine kinase that is highly expressed in the brain, is involved in neurite extension and apoptosis of cerebellar granule neurons; however, its precise function remains unknown.
Koji Tsutsumi +6 more
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Tyrosine phosphorylation of Grb14 by Tie2 [PDF]
Cell Communication and Signaling, 2010 Background Growth factor receptor bound (Grb) proteins 7, 10 and 14 are a family of structurally related multi-domain adaptor proteins involved in a variety of biological processes.
Dumont Daniel J, Sturk Celina
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Large‐scale phosphorylation mapping reveals the extent of tyrosine phosphorylation in Arabidopsis
Molecular Systems Biology, 2008 Protein phosphorylation regulates a wide range of cellular processes. Here, we report the proteome‐wide mapping of in vivo phosphorylation sites in Arabidopsis by using complementary phosphopeptide enrichment techniques coupled with high‐accuracy mass ...
Naoyuki Sugiyama +6 more
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Protein Tyrosine Phosphorylation in the Ischemic Brain
Journal of Pharmacological Sciences, 2014 .: Cerebral ischemia, a pathological condition in which brain tissue experiences a shortage of cerebral blood flow, is associated with cerebrovascular disease, brain trauma, epilepsy, and cardiac arrest.
Norio Takagi
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Src-dependent tyrosine-phosphorylation of NM2A has a protective role against bacterial pore-forming toxins. [PDF]
PLoS PathogensPore-forming toxins (PFTs) are key bacterial virulence factors that disrupt host plasma membrane (PM) integrity, triggering cellular stress and initiating repair mechanisms.
Cláudia Brito +10 more
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Membrane lipid rafts are required for AMPA receptor tyrosine phosphorylation [PDF]
Frontiers in Synaptic Neuroscience, 2022 Membrane lipid rafts are sphingolipids and cholesterol-enriched membrane microdomains, which form a center for the interaction or assembly of palmitoylated signaling molecules, including Src family non-receptor type protein tyrosine kinases.
Takashi Hayashi, Takashi Hayashi
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Anti-microbial cetylpyridinium chloride suppresses mast cell function by targeting tyrosine phosphorylation of Syk kinase [PDF]
Journal of ImmunotoxicologyCetylpyridinium chloride (CPC) is a quaternary ammonium antimicrobial used in numerous personal care products, human food, cosmetic products, and cleaning solutions. Yet, there is minimal published data on CPC effects on eukaryotes, immune signaling, and
Bright Obeng +16 more
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Tyrosine phosphorylation of both STAT5A and STAT5B is necessary for maximal IL-2 signaling and T cell proliferation [PDF]
Nature CommunicationsCytokine-mediated STAT5 protein activation is vital for lymphocyte development and function. In vitro tyrosine phosphorylation of a C-terminal tyrosine is critical for activation of STAT5A and STAT5B; however, the importance of STAT5 tyrosine ...
Jian-Xin Lin +9 more
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Bio-Protocol, 2022 Cells sense and respond to mitogens by activating a cascade of signaling events, primarily mediated by tyrosine phosphorylation (pY). Because of its key roles in cellular homeostasis, deregulation of this signaling is often linked to oncogenesis.
Vidyasiri Vemulapalli +3 more
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Interaction between O-GlcNAc modification and tyrosine phosphorylation of prohibitin: implication for a novel binary switch. [PDF]
PLoS ONE, 2009 Prohibitin (PHB or PHB1) is an evolutionarily conserved, multifunctional protein which is present in various cellular compartments including the plasma membrane. However, mechanisms involved in various functions of PHB are not fully explored yet. Here we
Sudharsana R Ande +2 more
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