Results 41 to 50 of about 1,485,018 (348)

Quercetin inhibits collagen-stimulated platelet activation through inhibition of multiple components of the glycoprotein VI signaling pathway [PDF]

, 2003
Background: The regulation of platelet function by pharmacological agents that modulate platelet signaling haspharmacolo proven a successful approach to the prevention of thrombosis.
Cicmil, M, C. M. Williams, G. P. Hubbard, T. Sage, Stevens, J M; id_orcid, P. A. Jordan, J. M. Gibbins, M. Cicmil, Sage, T, Gibbins, J.M., Williams, C M, Gibbins, J M, Jordan, P A, Lovegrove, J A, Hubbard, G P, J. A. Lovegrove, J. M. Stevens, Stevens, J.M., Williams, C.M., Jordan, P.A., Lovegrove, J.A., Hubbard, G.P., Cicmil, M., Sage, T.   +23 more
core   +1 more source

T cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase [PDF]

, 2001
After stimulation of the T cell receptor (TCR), the tyrosine residues 292 and 315 in interdomain B of the protein tyrosine kinase ZAP-70 become phosphorylated and plausibly function as docking sites for Cbl and Vav1, respectively. The two latter proteins
Anne Gillet, Antoine Magnan, Malissen, Bernard, Vincenzo Di Bartolo, Mireille Richelme, Marie Malissen, Gillet, A., Mura, A. M., Boyer, C., Arrieumerlou, C., Malissen, M., Roure, A., Lin, Y. L., Bernard Malissen, Claude Boyer, Malissen, B., Cécile Arrieumerlou, Yea-Lih Lin, Agnès Roure, Oreste Acuto, Acuto, O., Richelme, M., Di Bartolo, V., Anne-Marie Mura, Boyer, Claudine, Magnan, A.   +25 more
core   +1 more source

Genistein, a specific inhibitor of tyrosine-specific protein kinases.

Journal of Biological Chemistry, 1987
Tyrosine-specific protein kinase activity of the epidermal growth factor (EGF) receptor, pp60v-src and pp110gag-fes was inhibited in vitro by an isoflavone genistein.
Tetsu Akiyama, J. Ishida, Shinsaku Nakagawa, H. Ogawara, Shinya Watanabe, N. Itoh, M. Shibuya, Y. Fukami   +7 more
semanticscholar   +1 more source

On the Extent of Tyrosine Phosphorylation in Chloroplasts [PDF]

Plant Physiology, 2015
Reanalysis of published mass spectrometry data on Tyr-phosphorylated chloroplast proteins indicates that the majority of peptide spectrum matches reporting Tyr phosphorylation are ambiguous.
Qintao, Lu, Stefan, Helm, Anja, Rödiger, Sacha, Baginsky   +3 more
openaire   +2 more sources

Tyrosine hydroxylase phosphorylation is under the control of serine 40 [PDF]

, 2023
Tyrosine hydroxylase catalyzes the initial and rate-limiting step in the biosynthesis of the neurotransmitter dopamine. The phosphorylation state of Ser40 and Ser31 is believed to exert a direct effect on the enzymatic activity of tyrosine hydroxylase ...
Lars P. van der Heide, van der Heide, L.P.; id_orcid, Stoop, J., Douma, E.H.; id_orcid, van der Vlag, M., Smidt, M.P.; id_orcid, Jesse Stoop, Marten P. Smidt, Marc van der Vlag, Erik H. Douma   +9 more
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The overexpression of scaffolding protein NEDD9 promotes migration and invasion in cervical cancer via tyrosine phosphorylated FAK and SRC. [PDF]

PLoS ONE, 2013
NEDD9, a focal adhesion scaffolding protein, has been recently proposed to regulate invasion and metastasis in some cancer types, but unknown in cervical cancer.
Ni Sima, Xiaodong Cheng, Feng Ye, Ding Ma, Xing Xie, Weiguo Lü   +5 more
doaj   +1 more source

Mass Spectrometry and Pharmacological Approaches to Measuring Cooption and Reciprocal Activation of Receptor Tyrosine Kinases

Proteomes, 2023
Receptor tyrosine kinases (RTKs) can show extensive crosstalk, directly and indirectly. Elucidating RTK crosstalk remains an important goal in the clinical combination of anti-cancer therapies.
Jason Linzer, Zachary Phelps, Shivasuryan Vummidi, Bo Young Elizabeth Lee, Nicolas Coant, John D. Haley   +5 more
doaj   +1 more source

Phosphorylation of Tyrosine Aminotransferase in Vivo

Journal of Biological Chemistry, 1974
Abstract Incorporation of 32Pi into hepatic tyrosine aminotransferase (l-tyrosine:2-oxoglutarate aminotransferase; EC 2.6.1.5) was observed when the isotope was either administered into rats or added to the medium of cultured Reuber H-35 hepatoma cells.
K L, Lee, J M, Nickol
openaire   +2 more sources

Tyrosine phosphorylation of KAT5 (Tip60) couples chromatin sensing to ATM-dependent checkpoint signaling

Nature, 2013
The detection of DNA lesions within chromatin represents a critical step in cellular responses to DNA damage. However, the regulatory mechanisms that couple chromatin sensing to DNA-damage signalling in mammalian cells are not well understood.
Abderrahmane Kaidi, S. Jackson
semanticscholar   +1 more source

Analysis of Epithelial Growth Factor-Receptor (EGFR) Phosphorylation in Uterine Smooth Muscle Tumors [PDF]

, 2013
Uterine fibroids are the commonest uterine benign tumors. A potential mechanism of malignant transformation from leiomyomas to leiomyosarcomas has beendescribed.
Darius Dian, Antonis Makrigiannakis, Jeschke, Udo, Klaus Friese, Weissenbacher, Tobias, Mayr, Doris, David Roeder, Udo Jeschke, Nina Ditsch, Thomas Vrekoussis, Tobias Weissenbacher, Vrekoussis, Thomas, Dian, Darius, Ditsch, Nina, Friese, Klaus, Doris Mayr, Makrigiannakis, Antonis, Roeder, David   +17 more
core   +1 more source