Results 41 to 50 of about 288,999 (305)

Cbl-associated protein is tyrosine phosphorylated by c-Abl and c-Src kinases [PDF]

, 2009
Background: The c-Cbl-associated protein (CAP), also known as ponsin, localizes to focal adhesions and stress fibers and is involved in signaling events.
Tomasovic, Ana, Ana Tomasovic, Tikkanen Ritva, Fernow Inga, Inga Fernow, Siehoff-Icking, Ann, Fernow, Inga Susanne, Tikkanen, Ritva, Ann Siehoff-Icking, Tomasovic Ana, Siehoff-Icking Ann, Ritva Tikkanen   +11 more
core   +1 more source

Phosphorylation of Tyrosine Aminotransferase in Vivo

Journal of Biological Chemistry, 1974
Abstract Incorporation of 32Pi into hepatic tyrosine aminotransferase (l-tyrosine:2-oxoglutarate aminotransferase; EC 2.6.1.5) was observed when the isotope was either administered into rats or added to the medium of cultured Reuber H-35 hepatoma cells.
K L, Lee, J M, Nickol
openaire   +2 more sources

The overexpression of scaffolding protein NEDD9 promotes migration and invasion in cervical cancer via tyrosine phosphorylated FAK and SRC. [PDF]

PLoS ONE, 2013
NEDD9, a focal adhesion scaffolding protein, has been recently proposed to regulate invasion and metastasis in some cancer types, but unknown in cervical cancer.
Ni Sima, Xiaodong Cheng, Feng Ye, Ding Ma, Xing Xie, Weiguo Lü   +5 more
doaj   +1 more source

Mass Spectrometry and Pharmacological Approaches to Measuring Cooption and Reciprocal Activation of Receptor Tyrosine Kinases

Proteomes, 2023
Receptor tyrosine kinases (RTKs) can show extensive crosstalk, directly and indirectly. Elucidating RTK crosstalk remains an important goal in the clinical combination of anti-cancer therapies.
Jason Linzer, Zachary Phelps, Shivasuryan Vummidi, Bo Young Elizabeth Lee, Nicolas Coant, John D. Haley   +5 more
doaj   +1 more source

Charge environments around phosphorylation sites in proteins [PDF]

, 2008
Background: Phosphorylation is a central feature in many biological processes. Structural analyses have identified the importance of charge-charge interactions, for example mediating phosphorylation-driven allosteric change and protein binding to ...
Kitchen, James, Rebecca E Saunders, Jim Warwicker, Saunders, Rebecca E., Warwicker, Jim, Warwicker, Jim; id_orcid, James Kitchen   +6 more
core   +1 more source

Regulation of the tyrosine phosphorylation of Phospholipid Scramblase 1 in mast cells that are stimulated through the high-affinity IgE receptor. [PDF]

PLoS ONE, 2014
Engagement of high-affinity immunoglobulin E receptors (FcεRI) activates two signaling pathways in mast cells. The Lyn pathway leads to recruitment of Syk and to calcium mobilization whereas the Fyn pathway leads to phosphatidylinositol 3-kinase ...
Asma Kassas, Ivan C Moura, Yumi Yamashita, Jorg Scheffel, Claudine Guérin-Marchand, Ulrich Blank, Peter J Sims, Therese Wiedmer, Renato C Monteiro, Juan Rivera, Nicolas Charles, Marc Benhamou   +11 more
doaj   +1 more source

Protein tyrosine phosphatase TbPTP1:A molecular switch controlling life cycle differentiation in trypanosomes [PDF]

, 2006
Differentiation in African trypanosomes (Trypanosoma brucei) entails passage between a mammalian host, where parasites exist as a proliferative slender form or a G0-arrested stumpy form, and the tsetse fly.
Szoor, Balazs; id_orcid, Matthews, Keith R., Helen McElhinney, Tabernero, Lydia, Wilson, Jude, Szöor, Balázs, Keith R. Matthews, Matthews, Keith R; id_orcid, Lydia Tabernero, Tabernero, Lydia; id_orcid, McElhinney, Helen, Balázs Szöőr, Jude Wilson   +12 more
core   +1 more source

Tyrosine phosphorylation profiling in FGF-2 stimulated human embryonic stem cells. [PDF]

PLoS ONE, 2011
The role of fibroblast growth factor-2 (FGF-2) in maintaining undifferentiated human embryonic stem cells (hESC) was investigated using a targeted phosphoproteomics approach to specifically profile tyrosine phosphorylation events following FGF-2 ...
Vanessa M Y Ding, Paul J Boersema, Leong Yan Foong, Christian Preisinger, Geoffrey Koh, Subaashini Natarajan, Dong-Yup Lee, Jos Boekhorst, Berend Snel, Simone Lemeer, Albert J R Heck, Andre Choo   +11 more
doaj   +1 more source

Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2 [PDF]

, 2002
Receptor tyrosine kinases (RTKs) play distinct roles in multiple biological systems. Many RTKs transmit similar signals, raising questions about how specificity is achieved.
Zhang, S., Wen, G., Minichiello, L., Zhang, Si Qing, Wen, Gengyun, Araki, T., Klein, R., Tsiaras, B., Neel, Benjamin G, Neel, B., Araki, Toshiyuki, Klein, Ruediger, Minichiello, Liliana, Tsiaras, William G   +13 more
core   +1 more source

Identification of tyrosine-9 of MAVS as critical target for inducible phosphorylation that determines activation.

PLoS ONE, 2012
BackgroundInnate immunity to viruses involves receptors such as RIG-I, which senses viral RNA and triggers an IFN-β signaling pathway involving the outer mitochondrial membrane protein MAVS.
Chaoyang Wen, Zhifeng Yan, Xiaoli Yang, Kai Guan, Changzhi Xu, Ting Song, Zirui Zheng, Wenjun Wang, Ying Wang, Man Zhao, Yanhong Zhang, Tao Xu, Jianping Dou, Jingmei Liu, Quanbin Xu, Xiang He, Congwen Wei, Hui Zhong   +17 more
doaj   +1 more source