Results 61 to 70 of about 1,485,018 (348)

Computational identification of phospho-tyrosine sub-networks related to acanthocyte generation in neuroacanthocytosis [PDF]

, 2012
Acanthocytes, abnormal thorny red blood cells (RBC), are one of the biological hallmarks of neuroacanthocytosis syndromes (NA), a group of rare hereditary neurodegenerative disorders.
Pantaleo, Antonella, Angela Siciliano, Jung, Hans H., Pantaleo A., Ruth H. Walker (184548), Dotti Maria Teresa, Bader B., Sara Mazzucco, Lucia De Franceschi (184533), Dotti, Maria Teresa, Tomelleri Carlo, Bader, B, Hans H. Jung (184555), Walker R. H., Mazzucco, Sara, Walker, R H, Scardoni, G, Danek, A, Carlo Tomelleri, Giovanni Scardoni, Sara Mazzucco (184565), Scardoni G, Bader Benedikt, Dotti, M T, Siciliano, Angela, Danek, Adrian, Tomelleri C, Lucia De Franceschi, Giovanni Scardoni (184538), Adrian Danek, Antonella Pantaleo (184574), Pantaleo, A, Pantaleo Antonella, Laudanna Carlo, Jung H. H., Benedikt Bader, Adrian Danek (4947), De Franceschi Lucia, Scardoni G., Siciliano A, Antonella Pantaleo, Danek Adrian, Tomelleri, Carlo, Hans H Jung, Jung, H H, Carlo Laudanna (184575), Laudanna C., Benedikt Bader (184560), Jung Hans H., DOTTI, MARIA, De Franceschi L, Jung HH, Tomelleri, C, Walker RH, De Franceschi, L, Pantaleo A, Laudanna, Carlo, Danek A, Carlo Laudanna, Siciliano, A, De Franceschi, Lucia, Maria Teresa Dotti (184569), Walker Ruth H., Scardoni, Giovanni, Ruth H Walker, Maria Teresa Dotti, Mazzucco Sara, Bader B, Scardoni Giovanni, Mazzucco, S, Dotti M. T., Laudanna, C, Angela Siciliano (184571), Siciliano Angela, Carlo Tomelleri (184542), Walker, Ruth H., Bader, Benedikt, Mazzucco S, Danek A.   +78 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Tyrosine Phosphorylation of Caspase-8 Abrogates Its Apoptotic Activity and Promotes Activation of c-Src. [PDF]

PLoS ONE, 2016
Src family tyrosine kinases (SFKs) phosphorylate caspase-8A at tyrosine (Y) 397 resulting in suppression of apoptosis. In addition, the phosphorylation of caspase-8A at other sites including Y465 has been implicated in the regulation of caspase-8 ...
Jennifer Ly Tsang, Song Hui Jia, Jean Parodo, Pamela Plant, Monika Lodyga, Emmanuel Charbonney, Katalin Szaszi, Andras Kapus, John C Marshall   +8 more
doaj   +1 more source

Laminin-1 redistributes postsynaptic proteins and requires rapsyn, tyrosine phosphorylation, and Src and Fyn to stably cluster acetylcholine receptors

Journal of Cell Biology, 2002
Clustering of acetylcholine receptors (AChRs) is a critical step in neuromuscular synaptogenesis, and is induced by agrin and laminin which are thought to act through different signaling mechanisms. We addressed whether laminin redistributes postsynaptic
P. Marangi, Simon T. Wieland, Christian Fuhrer   +2 more
semanticscholar   +1 more source

A possible tyrosine phosphorylation of phytochrome

FEBS Letters, 1996
Red/far‐red light signal transduction by the phytochrome family of photoreceptors regulates plant growth and development. We investigated the possibility that tyrosine kinases and/or phosphatases are involved in phytochrome‐mediated signal transduction using crude extracts of oat seedlings that are grown in the dark. We found that a 124 kDa protein was
Sommer, Debbie, Wells, Todd A., Pill-Soon Song,   +2 more
openaire   +2 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Integrin Ligation Results in Nephrin Tyrosine Phosphorylation In Vitro. [PDF]

PLoS ONE, 2016
Nephrin is expressed at the basolateral aspect of podocytes and is an important signaling protein at the glomerular slit diaphragm. In vitro studies have demonstrated that Nephrin phosphorylation-dependent signaling is able to assemble a protein complex ...
Rakesh Verma, Madhusudan Venkatareddy, Anne Kalinowski, Sanjeevkumar R Patel, Puneet Garg   +4 more
doaj   +1 more source

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

Science Signaling, 2009
Tyrosine phosphorylation of pyruvate kinase M2 gives tumor cells a metabolic advantage. A Malignant Metabolic Switch Cancer cells show aberrant metabolism, consuming more glucose than do healthy cells and producing lactate even in the presence of ...
T. Hitosugi, Su-Min Kang, M. V. Vander Heiden, Tae-Wook Chung, Shannon E. Elf, Katherine Lythgoe, Shao-Zhong Dong, S. Lonial, Xu Wang, G. Chen, Jianxin Xie, T. Gu, R. Polakiewicz, J. Roesel, T. Boggon, F. Khuri, D. Gilliland, L. Cantley, J. Kaufman, Jing Chen   +19 more
semanticscholar   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Vanadate Activates Rho A Translocation in Association With Contracting Effects in Ileal Longitudinal Smooth Muscle of Guinea Pig

Journal of Pharmacological Sciences, 2004
We characterized the effects of vanadate, an inhibitor of tyrosine phosphatase, on the tension, the level of myosin light chain (MLC) phosphorylation, and Rho A activation in intact ileal longitudinal smooth muscle of the guinea pig to study the role of ...
Mayumi Mori, Hiromi Tsushima
doaj   +1 more source