Results 61 to 70 of about 288,999 (305)

Tyrosine Phosphorylation Regulates Maturation of Receptor Tyrosine Kinases [PDF]

Molecular and Cellular Biology, 2005
Constitutive activation of receptor tyrosine kinases (RTKs) is a frequent event in human cancer cells. Activating mutations in Fms-like tyrosine kinase 3 (FLT-3), notably, internal tandem duplications in the juxtamembrane domain (FLT-3 ITD), have been causally linked to acute myeloid leukemia.
Dirk-E, Schmidt-Arras, Annette, Böhmer, Boyka, Markova, Chunaram, Choudhary, Hubert, Serve, Frank-D, Böhmer   +5 more
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Vanadate Activates Rho A Translocation in Association With Contracting Effects in Ileal Longitudinal Smooth Muscle of Guinea Pig

Journal of Pharmacological Sciences, 2004
We characterized the effects of vanadate, an inhibitor of tyrosine phosphatase, on the tension, the level of myosin light chain (MLC) phosphorylation, and Rho A activation in intact ileal longitudinal smooth muscle of the guinea pig to study the role of ...
Mayumi Mori, Hiromi Tsushima
doaj   +1 more source

Integrin Ligation Results in Nephrin Tyrosine Phosphorylation In Vitro. [PDF]

PLoS ONE, 2016
Nephrin is expressed at the basolateral aspect of podocytes and is an important signaling protein at the glomerular slit diaphragm. In vitro studies have demonstrated that Nephrin phosphorylation-dependent signaling is able to assemble a protein complex ...
Rakesh Verma, Madhusudan Venkatareddy, Anne Kalinowski, Sanjeevkumar R Patel, Puneet Garg   +4 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

The differential regulation of Lck kinase phosphorylation sites by CD45 is critical for T cell receptor signaling responses [PDF]

, 2007
The molecular mechanisms whereby the CD45 tyrosine phosphatase (PTPase) regulates T cell receptor (TCR) signaling responses remain to be elucidated. To investigate this question, we have reconstituted CD45 (encoded by Ptprc)-deficient mice, which display
Cooper, Joanne C, Alexander, Denis R, Cassady-Cain, Robin L., Salmond, Robert J., Tandon, Panna, Roche-Molina, Marta, Carret, Céline K., Holmes, Nick, McNeill, Louise, Cassady-Cain, Robin, Cooper, Joanne C., Alexander, Denis R., Carret, Celine K   +12 more
core   +1 more source

Sorafenib inhibits LPS-induced inflammation by regulating Lyn-MAPK-NF-kB/AP-1 pathway and TLR4 expression

Cell Death Discovery, 2022
Sorafenib is an anti-tumor drug widely used in clinical treatment, which can inhibit tyrosine kinase receptor on cell surface and serine/threonine kinase in downstream Ras/MAPK cascade signaling pathway of cells.
Xiaolian Li, Mingkun Xu, Jiaojiao Shen, Yuqin Li, Shaoping Lin, Min Zhu, Qiongni Pang, Xiujuan Tan, Jing Tang   +8 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

The Effect of Social Defeat on Tyrosine Hydroxylase Phosphorylation in the Rat Brain and Adrenal Gland [PDF]

, 2010
Tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, is regulated acutely by protein phosphorylation and chronically by protein synthesis.
Lin Kooi Ong, Ong, Lin Kooi, Peter R. Dunkley, Dickson, Phillip W., Bobrovskaya, Larisa, Walker, Frederick R., Day, Trevor A., Dunkley, Peter R., Phillip W. Dickson, Frederick R. Walker, Trevor A. Day, Larisa Bobrovskaya   +11 more
core   +1 more source

A Requirement for SOCS-1 and SOCS-3 Phosphorylation in Bcr-Abl-Induced Tumorigenesis

Neoplasia: An International Journal for Oncology Research, 2012
Suppressors of cytokine signaling 1 and 3 (SOCS-1 and SOCS-3) are inhibitors of the Janus tyrosine kinase (JAK)/signal transducers and activators of transcription (STAT) pathway and function in a negative feedback loop during cytokine signaling.
Xiaoxue Qiu, Guijie Guo, Ke Chen, Masaki Kashiwada, Brian J. Druker, Paul B. Rothman, Ji-Long Chen   +6 more
doaj   +1 more source