Results 1 to 10 of about 11,155,248 (357)
Role of protein phosphorylation in cell signaling, disease, and the intervention therapy
MedComm, 2022 Protein phosphorylation is an important post‐transcriptional modification involving an extremely wide range of intracellular signaling transduction pathways, making it an important therapeutic target for disease intervention.
Zhe-Sheng Chen
exaly +2 more sources
Protein phosphorylation and its role in archaeal signal transduction
FEMS Microbiology Reviews, 2016 Reversible protein phosphorylation is the main mechanism of signal transduction that enables cells to rapidly respond to environmental changes by controlling the functional properties of proteins in response to external stimuli.
Wen Qiu +2 more
exaly +2 more sources
Protein phosphorylation: A molecular switch in plant signaling.
Cell Reports, 2023 Protein phosphorylation modification is crucial for signaling transduction in plant development and environmental adaptation. By precisely phosphorylating crucial components in signaling cascades, plants can switch on and off the specific signaling ...
Wen-Jie Zhang +4 more
semanticscholar +1 more source
Pacritinib abrogates the lupus phenotype in ABIN1[D485N] mice
Lupus Science and Medicine, 2023 Objective The aim of the study was to investigate whether the IRAK1/JAK2/Flt3 inhibitor pacritinib prevents disease development in the lupus-prone ABIN1[D485N] knock-in mouse.Methods ABIN1[D485N] knock-in mice aged 8 weeks were fed for 10 weeks on a diet
Philip Cohen +4 more
doaj +1 more source
A current view on Tau protein phosphorylation in Alzheimer's disease.
Current Opinion in Neurobiology, 2021 The functions of the neuronal microtubule-associated protein Tau in the central nervous system are regulated by manifold posttranslational modifications at more than 50 sites.
Susanne Wegmann +2 more
semanticscholar +1 more source
Dissecting the role of protein phosphorylation: a chemical biology toolbox.
Chemical Society Reviews, 2022 Protein phosphorylation is a crucial regulator of protein and cellular function, yet, despite identifying an enormous number of phosphorylation sites, the role of most is still unclear. Each phosphoform, the particular combination of phosphorylations, of
Timothy S. Bilbrough +2 more
semanticscholar +1 more source
Systematic discovery of biomolecular condensate-specific protein phosphorylation
Nature Chemical Biology, 2022 Reversible protein phosphorylation is an important mechanism for regulating (dis)assembly of biomolecular condensates. However, condensate-specific phosphosites remain largely unknown, thereby limiting our understanding of the underlying mechanisms. Here,
Sindhuja Sridharan +9 more
semanticscholar +1 more source
Protein Phosphorylation in Cancer: Role of Nitric Oxide Signaling Pathway
Biomolecules, 2021 Nitric oxide (NO), a free radical, plays a critical role in a wide range of physiological and pathological processes. Due to its pleiotropic function, it has been widely investigated in various types of cancers and is strongly associated with cancer ...
Xinran Liu +5 more
semanticscholar +1 more source
PHYTOCHROME and PROTEIN PHOSPHORYLATION [PDF]
Photochemistry and Photobiology, 1990 Abstract— The molecular mode of signal transduction triggered by phytochrome is unknown. One characteristic structural/topographic feature of the physiologically active form (Pfr) of phytochrome is that its tetrapyrrole chromophore becomes preferentially exposed in the Pfr form (compared to the Pr form).
B R, Singh, P S, Song
openaire +2 more sources
IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes
Nature Communications, 2021 Intraepithelial lymphocytes (IEL) respond to IL-15 complexed with IL-15Ra but how this intrinsically affects IEL is unclear. Here the authors use proteomics analyses of the main mouse IEL subsets and identify PIM kinases as essential for IEL ...
Olivia J. James +7 more
doaj +1 more source